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1ufu
From Proteopedia
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==Crystal structure of ligand binding domain of immunoglobulin-like transcript 2 (ILT2; LIR-1)== | ==Crystal structure of ligand binding domain of immunoglobulin-like transcript 2 (ILT2; LIR-1)== | ||
| - | <StructureSection load='1ufu' size='340' side='right' caption='[[1ufu]], [[Resolution|resolution]] 3.00Å' scene=''> | + | <StructureSection load='1ufu' size='340' side='right'caption='[[1ufu]], [[Resolution|resolution]] 3.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1ufu]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1ufu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UFU FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ufu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ufu OCA], [https://pdbe.org/1ufu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ufu RCSB], [https://www.ebi.ac.uk/pdbsum/1ufu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ufu ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uf/1ufu_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uf/1ufu_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ufu ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | |||
| - | ==See Also== | ||
| - | *[[Leukocyte immunoglobulin-like receptor|Leukocyte immunoglobulin-like receptor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Amano | + | [[Category: Large Structures]] |
| - | [[Category: Kohda | + | [[Category: Amano K]] |
| - | [[Category: Kumagai | + | [[Category: Kohda D]] |
| - | [[Category: Maenaka | + | [[Category: Kumagai I]] |
| - | [[Category: Rasubala | + | [[Category: Maenaka K]] |
| - | [[Category: Shiroishi | + | [[Category: Rasubala L]] |
| - | [[Category: Tsumoto | + | [[Category: Shiroishi M]] |
| - | + | [[Category: Tsumoto K]] | |
| - | + | ||
Current revision
Crystal structure of ligand binding domain of immunoglobulin-like transcript 2 (ILT2; LIR-1)
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Categories: Homo sapiens | Large Structures | Amano K | Kohda D | Kumagai I | Maenaka K | Rasubala L | Shiroishi M | Tsumoto K
