3f70

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==Crystal structure of L3MBTL2-H4K20me1 complex==
==Crystal structure of L3MBTL2-H4K20me1 complex==
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<StructureSection load='3f70' size='340' side='right' caption='[[3f70]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3f70' size='340' side='right'caption='[[3f70]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3f70]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3dbb 3dbb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F70 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F70 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3f70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3dbb 3dbb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F70 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cey|3cey]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">L3MBTL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f70 OCA], [https://pdbe.org/3f70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f70 RCSB], [https://www.ebi.ac.uk/pdbsum/3f70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f70 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f70 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f70 RCSB], [http://www.ebi.ac.uk/pdbsum/3f70 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LMBL2_HUMAN LMBL2_HUMAN]] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.<ref>PMID:19233876</ref>
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[https://www.uniprot.org/uniprot/LMBL2_HUMAN LMBL2_HUMAN] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.<ref>PMID:19233876</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/3f70_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/3f70_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f70 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3f70" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Allali-Hassani, A]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Allali-Hassani A]]
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[[Category: Botchkarev, A]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Botchkarev A]]
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[[Category: Crombet, L]]
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[[Category: Bountra C]]
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[[Category: Dong, A]]
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[[Category: Crombet L]]
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[[Category: Edwards, A M]]
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[[Category: Dong A]]
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[[Category: Guo, Y]]
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[[Category: Edwards AM]]
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[[Category: Kozieradzki, I]]
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[[Category: Guo Y]]
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[[Category: Loppnau, P]]
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[[Category: Kozieradzki I]]
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[[Category: Mackenzie, F]]
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[[Category: Loppnau P]]
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[[Category: Min, J]]
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[[Category: Mackenzie F]]
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[[Category: Pan, P]]
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[[Category: Min J]]
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[[Category: Qi, C]]
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[[Category: Pan P]]
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[[Category: Read, R]]
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[[Category: Qi C]]
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[[Category: Structural genomic]]
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[[Category: Read R]]
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[[Category: Vedadi, M]]
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[[Category: Vedadi M]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Zhu, H]]
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[[Category: Zhu H]]
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[[Category: Chromatin regulator]]
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[[Category: Mbt]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Sgc]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription regulator]]
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[[Category: Zinc-finger]]
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Current revision

Crystal structure of L3MBTL2-H4K20me1 complex

PDB ID 3f70

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