4fcp
From Proteopedia
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==Targetting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo [2,3-d] pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization== | ==Targetting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo [2,3-d] pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization== | ||
| - | <StructureSection load='4fcp' size='340' side='right' caption='[[4fcp]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='4fcp' size='340' side='right'caption='[[4fcp]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4fcp]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4fcp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FCP FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=42C:N,N-DIMETHYL-7H-PURIN-6-AMINE'>42C</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcp OCA], [https://pdbe.org/4fcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fcp RCSB], [https://www.ebi.ac.uk/pdbsum/4fcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fcp ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> |
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==See Also== | ==See Also== | ||
| - | *[[Heat Shock | + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Brough | + | [[Category: Large Structures]] |
| - | [[Category: Browne | + | [[Category: Brough P]] |
| - | [[Category: Davies | + | [[Category: Browne H]] |
| - | [[Category: Davies | + | [[Category: Davies B]] |
| - | [[Category: Drysdale | + | [[Category: Davies NGM]] |
| - | [[Category: Foloppe | + | [[Category: Drysdale M]] |
| - | [[Category: Geoffrey | + | [[Category: Foloppe N]] |
| - | [[Category: Gibbons | + | [[Category: Geoffrey S]] |
| - | [[Category: Hart | + | [[Category: Gibbons B]] |
| - | [[Category: Jensen | + | [[Category: Hart T]] |
| - | [[Category: Mansell | + | [[Category: Jensen MR]] |
| - | [[Category: Massey | + | [[Category: Mansell H]] |
| - | [[Category: Matassova | + | [[Category: Massey A]] |
| - | [[Category: Moore | + | [[Category: Matassova N]] |
| - | [[Category: Murray | + | [[Category: Moore JD]] |
| - | [[Category: Pratt | + | [[Category: Murray J]] |
| - | [[Category: Ray | + | [[Category: Pratt R]] |
| - | [[Category: Roughley | + | [[Category: Ray S]] |
| - | [[Category: Schoepfer | + | [[Category: Roughley SD]] |
| - | [[Category: Scriven | + | [[Category: Schoepfer J]] |
| - | [[Category: Simmonite | + | [[Category: Scriven K]] |
| - | [[Category: Stokes | + | [[Category: Simmonite H]] |
| - | [[Category: Surgenor | + | [[Category: Stokes S]] |
| - | [[Category: Webb | + | [[Category: Surgenor A]] |
| - | [[Category: Wright | + | [[Category: Webb P]] |
| - | + | [[Category: Wright L]] | |
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Current revision
Targetting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo [2,3-d] pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization
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Categories: Homo sapiens | Large Structures | Brough P | Browne H | Davies B | Davies NGM | Drysdale M | Foloppe N | Geoffrey S | Gibbons B | Hart T | Jensen MR | Mansell H | Massey A | Matassova N | Moore JD | Murray J | Pratt R | Ray S | Roughley SD | Schoepfer J | Scriven K | Simmonite H | Stokes S | Surgenor A | Webb P | Wright L
