3pry
From Proteopedia
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==Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution== | ==Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution== | ||
| - | <StructureSection load='3pry' size='340' side='right' caption='[[3pry]], [[Resolution|resolution]] 2.28Å' scene=''> | + | <StructureSection load='3pry' size='340' side='right'caption='[[3pry]], [[Resolution|resolution]] 2.28Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3pry]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3pry]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PRY FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pry OCA], [https://pdbe.org/3pry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pry RCSB], [https://www.ebi.ac.uk/pdbsum/3pry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pry ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref> |
==See Also== | ==See Also== | ||
| - | *[[Heat Shock | + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Ayinampudi | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Berridge | + | [[Category: Ayinampudi V]] |
| - | [[Category: Bountra | + | [[Category: Berridge G]] |
| - | [[Category: Bullock | + | [[Category: Bountra C]] |
| - | [[Category: Chaikuad | + | [[Category: Bullock A]] |
| - | [[Category: Che | + | [[Category: Chaikuad A]] |
| - | [[Category: Cooper | + | [[Category: Che KH]] |
| - | + | [[Category: Cooper CDO]] | |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Fedorov | + | [[Category: Fedorov O]] |
| - | [[Category: Keates | + | [[Category: Keates T]] |
| - | [[Category: Krojer | + | [[Category: Krojer T]] |
| - | [[Category: Muniz | + | [[Category: Muniz JRC]] |
| - | [[Category: Phillips | + | [[Category: Phillips C]] |
| - | [[Category: Pilka | + | [[Category: Pilka E]] |
| - | + | [[Category: Sharpe TD]] | |
| - | [[Category: Sharpe | + | [[Category: Thangaratnarajah C]] |
| - | [[Category: Thangaratnarajah | + | [[Category: Vollmar M]] |
| - | [[Category: Vollmar | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Yue WW]] |
| - | [[Category: Yue | + | [[Category: Zimmermann T]] |
| - | [[Category: Zimmermann | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
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Current revision
Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Ayinampudi V | Berridge G | Bountra C | Bullock A | Chaikuad A | Che KH | Cooper CDO | Edwards A | Fedorov O | Keates T | Krojer T | Muniz JRC | Phillips C | Pilka E | Sharpe TD | Thangaratnarajah C | Vollmar M | Weigelt J | Yue WW | Zimmermann T | Von Delft F
