2bzt
From Proteopedia
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| - | [[Image:2bzt.jpg|left|200px]] | ||
| - | + | ==NMR structure of the bacterial protein YFHJ from E. coli== | |
| - | + | <StructureSection load='2bzt' size='340' side='right'caption='[[2bzt]]' scene=''> | |
| - | | | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[2bzt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BZT FirstGlance]. <br> | |
| - | | | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | | | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bzt OCA], [https://pdbe.org/2bzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bzt RCSB], [https://www.ebi.ac.uk/pdbsum/2bzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bzt ProSAT]</span></td></tr> |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ISCX_ECOLI ISCX_ECOLI] May function as iron donor in the assembly of iron-sulfur clusters. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/2bzt_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bzt ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The yfhJ gene is part of the isc operon, which encodes the machinery devoted to assemble iron-sulfur clusters in prokaryotes. Its transcript is a small acidic protein that binds the desulfurase IscS, which is essential in iron-specific metabolic pathways. To understand its cellular role, we have characterized the structure of YfhJ in solution and its interactions with potential cellular partners. It contains a modified winged helix motif, usually present in DNA binding proteins, and is able to bind iron cations. The IscS interaction surface is the same as that involved in iron binding. This observation and the pattern of conservation through species strongly suggest that YfhJ is a molecular adaptor that is able to modulate the function of IscS in iron-sulfur cluster formation. The remarkable similarity between the in vitro behavior of YfhJ and that of the protein frataxin also suggests new hypotheses regarding the functional role of both proteins. | ||
| - | + | YfhJ, a molecular adaptor in iron-sulfur cluster formation or a frataxin-like protein?,Pastore C, Adinolfi S, Huynen MA, Rybin V, Martin S, Mayer M, Bukau B, Pastore A Structure. 2006 May;14(5):857-67. PMID:16698547<ref>PMID:16698547</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2bzt" style="background-color:#fffaf0;"></div> | |
| - | [[Category: Escherichia coli]] | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Adinolfi | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Escherichia coli K-12]] |
| - | [[Category: Pastore | + | [[Category: Large Structures]] |
| - | [[Category: Pastore | + | [[Category: Adinolfi S]] |
| - | + | [[Category: Kelly G]] | |
| - | + | [[Category: Mc Cormick JE]] | |
| - | + | [[Category: Pastore A]] | |
| - | + | [[Category: Pastore C]] | |
| - | + | ||
| - | + | ||
Current revision
NMR structure of the bacterial protein YFHJ from E. coli
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