2vky

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==HEADBINDING DOMAIN OF PHAGE P22 TAILSPIKE C-TERMINALLY FUSED TO ISOLEUCINE ZIPPER pIIGCN4 (CHIMERA I)==
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<StructureSection load='2vky' size='340' side='right' caption='[[2vky]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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==Headbinding Domain of Phage P22 Tailspike C-Terminally Fused to Isoleucine Zipper pIIGCN4 (Chimera I)==
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<StructureSection load='2vky' size='340' side='right'caption='[[2vky]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vky]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpp22 Bpp22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VKY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vky]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Salmonella_virus_P22 Salmonella virus P22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VKY FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lkt|1lkt]], [[1qa1|1qa1]], [[1qa2|1qa2]], [[1qa3|1qa3]], [[1qrb|1qrb]], [[1tyv|1tyv]], [[2vfm|2vfm]], [[1clw|1clw]], [[1qq1|1qq1]], [[1qrc|1qrc]], [[1tsp|1tsp]], [[2vfn|2vfn]], [[2vfo|2vfo]], [[2vfp|2vfp]], [[2vfq|2vfq]], [[2vnl|2vnl]], [[2xc1|2xc1]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vky RCSB], [http://www.ebi.ac.uk/pdbsum/2vky PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vky OCA], [https://pdbe.org/2vky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vky RCSB], [https://www.ebi.ac.uk/pdbsum/2vky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vky ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TSPE_BPP22 TSPE_BPP22]] Non-covalently bound to the neck of the phage capsid and mediating attachment of the viral particle to host cell-surface polysaccharide. It displays endorhamnosidase enzymatic activity, hydrolyzing the alpha-1,3-O-glycosidic linkage between rhamnose and galactose of the O-antigen polysaccharide.<ref>PMID:12837775</ref> <ref>PMID:20817910</ref>
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[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.[https://www.uniprot.org/uniprot/FIBER_BPP22 FIBER_BPP22] Structural component of the short non-contractile tail. The tail comprises six fibers that mediate primary attachment to the host cell lipopolysaccharides (LPS) and display endorhamnosidase enzymatic activity, hydrolyzing the alpha-1,3-O-glycosidic linkage between rhamnose and galactose of the O-antigen polysaccharide. Digestion of the LPS brings the capsid near the cell outer membrane.<ref>PMID:12837775</ref> <ref>PMID:20817910</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vky_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vky_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vky ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2vky" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tailspike protein 3D structures|Tailspike protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bpp22]]
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[[Category: Large Structures]]
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[[Category: Heinemann, U]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Mueller, G]]
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[[Category: Salmonella virus P22]]
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[[Category: Mueller, J J]]
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[[Category: Heinemann U]]
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[[Category: Seckler, R]]
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[[Category: Mueller G]]
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[[Category: Seul, A]]
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[[Category: Mueller JJ]]
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[[Category: Chimera]]
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[[Category: Seckler R]]
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[[Category: Head-binding domain]]
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[[Category: Seul A]]
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[[Category: Hydrolase]]
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[[Category: Isoleucine zipper piigcn4]]
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[[Category: Late protein]]
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[[Category: Phage p22 tailspike]]
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[[Category: Viral protein]]
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Current revision

Headbinding Domain of Phage P22 Tailspike C-Terminally Fused to Isoleucine Zipper pIIGCN4 (Chimera I)

PDB ID 2vky

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