2nxy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:22, 6 November 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
 +
==HIV-1 gp120 Envelope Glycoprotein(S334A) Complexed with CD4 and Antibody 17b==
==HIV-1 gp120 Envelope Glycoprotein(S334A) Complexed with CD4 and Antibody 17b==
-
<StructureSection load='2nxy' size='340' side='right' caption='[[2nxy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+
<StructureSection load='2nxy' size='340' side='right'caption='[[2nxy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2nxy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NXY FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2nxy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NXY FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gc1|1gc1]], [[1rzj|1rzj]], [[1rzk|1rzk]], [[2nxz|2nxz]], [[2ny0|2ny0]], [[2ny1|2ny1]], [[2ny2|2ny2]], [[2ny3|2ny3]], [[2ny4|2ny4]], [[2ny5|2ny5]], [[2ny6|2ny6]], [[2ny7|2ny7]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nxy OCA], [https://pdbe.org/2nxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nxy RCSB], [https://www.ebi.ac.uk/pdbsum/2nxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nxy ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nxy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nxy RCSB], [http://www.ebi.ac.uk/pdbsum/2nxy PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/CD4_HUMAN CD4_HUMAN]] Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
+
[https://www.uniprot.org/uniprot/Q49DS8_9HIV1 Q49DS8_9HIV1]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nx/2nxy_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nx/2nxy_consurf.spt"</scriptWhenChecked>
-
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nxy ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 28: Line 28:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 2nxy" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Antibody|Antibody]]
+
*[[Antibody 3D structures|Antibody 3D structures]]
*[[CD4|CD4]]
*[[CD4|CD4]]
-
*[[Gp120|Gp120]]
+
*[[CD4 3D structures|CD4 3D structures]]
 +
*[[Gp120 3D structures|Gp120 3D structures]]
 +
*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
Line 39: Line 42:
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
-
[[Category: Arthos, J]]
+
[[Category: Large Structures]]
-
[[Category: Burton, D R]]
+
[[Category: Arthos J]]
-
[[Category: Dey, B]]
+
[[Category: Burton DR]]
-
[[Category: Dimitrov, D S]]
+
[[Category: Dey B]]
-
[[Category: Hessell, A J]]
+
[[Category: Dimitrov DS]]
-
[[Category: Kwong, P D]]
+
[[Category: Hessell AJ]]
-
[[Category: Nabel, G J]]
+
[[Category: Kwong PD]]
-
[[Category: Ryk, D Van]]
+
[[Category: Nabel GJ]]
-
[[Category: Sodroski, J]]
+
[[Category: Sodroski J]]
-
[[Category: Wyatt, R]]
+
[[Category: Van Ryk D]]
-
[[Category: Xiang, S H]]
+
[[Category: Wyatt R]]
-
[[Category: Xu, L]]
+
[[Category: Xiang SH]]
-
[[Category: Yang, X]]
+
[[Category: Xu L]]
-
[[Category: Zhang, M Y]]
+
[[Category: Yang X]]
-
[[Category: Zhou, T]]
+
[[Category: Zhang MY]]
-
[[Category: Zwick, M B]]
+
[[Category: Zhou T]]
-
[[Category: Antibody]]
+
[[Category: Zwick MB]]
-
[[Category: Cd4]]
+
-
[[Category: Gp120]]
+
-
[[Category: Hiv]]
+
-
[[Category: Viral protein-immune system complex]]
+

Current revision

HIV-1 gp120 Envelope Glycoprotein(S334A) Complexed with CD4 and Antibody 17b

PDB ID 2nxy

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2nxy"
Personal tools