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4qd2

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==Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex==
==Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex==
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<StructureSection load='4qd2' size='340' side='right' caption='[[4qd2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4qd2' size='340' side='right'caption='[[4qd2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum_A_str._Hall Clostridium botulinum A str. Hall] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qd2 PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [https://pdbe.org/4qd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [https://www.ebi.ac.uk/pdbsum/4qd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qd2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CADH1_MOUSE CADH1_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).
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[https://www.uniprot.org/uniprot/A5HZZ6_CLOBH A5HZZ6_CLOBH]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4qd2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cadherin 3D structures|Cadherin 3D structures]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dong, M]]
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[[Category: Clostridium botulinum A str. Hall]]
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[[Category: Dorner, M B]]
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[[Category: Large Structures]]
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[[Category: Gu, S]]
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[[Category: Mus musculus]]
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[[Category: Jin, R]]
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[[Category: Dong M]]
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[[Category: Kruel, A]]
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[[Category: Dorner MB]]
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[[Category: Lee, K]]
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[[Category: Gu S]]
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[[Category: Perry, K]]
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[[Category: Jin R]]
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[[Category: Rummel, A]]
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[[Category: Kruel A]]
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[[Category: Zhong, X]]
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[[Category: Lee K]]
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[[Category: Botulinum neurotoxin]]
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[[Category: Perry K]]
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[[Category: Cell adhesion]]
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[[Category: Rummel A]]
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[[Category: E-cadherin]]
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[[Category: Zhong X]]
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[[Category: Ha17]]
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[[Category: Ha33]]
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[[Category: Ha70]]
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[[Category: Oral toxicity]]
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Current revision

Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex

PDB ID 4qd2

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