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1vmp

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==STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II==
==STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II==
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<StructureSection load='1vmp' size='340' side='right' caption='[[1vmp]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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<StructureSection load='1vmp' size='340' side='right'caption='[[1vmp]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1vmp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VMP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1vmp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VMP FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vmp RCSB], [http://www.ebi.ac.uk/pdbsum/1vmp PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vmp OCA], [https://pdbe.org/1vmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vmp RCSB], [https://www.ebi.ac.uk/pdbsum/1vmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vmp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VMI2_HHV8 VMI2_HHV8]] Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.
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[https://www.uniprot.org/uniprot/VMI2_HHV8P VMI2_HHV8P] Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vm/1vmp_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vm/1vmp_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vmp ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1vmp" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human herpesvirus 8]]
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[[Category: Human gammaherpesvirus 8]]
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[[Category: Liwang, A C]]
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[[Category: Large Structures]]
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[[Category: Liwang, P J]]
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[[Category: Liwang AC]]
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[[Category: Peiper, S C]]
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[[Category: Liwang PJ]]
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[[Category: Sun, Y]]
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[[Category: Peiper SC]]
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[[Category: Wang, Z X]]
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[[Category: Sun Y]]
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[[Category: Antiviral protein]]
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[[Category: Wang Z-X]]
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[[Category: Chemokine]]
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[[Category: Herpesvirus]]
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[[Category: Hhv-8]]
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[[Category: Kaposis']]
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[[Category: Monomer]]
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[[Category: Sarcoma]]
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[[Category: Vmip-ii]]
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Current revision

STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II

PDB ID 1vmp

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