3p4u
From Proteopedia
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==Crystal structure of active caspase-6 in complex with Ac-VEID-CHO inhibitor== | ==Crystal structure of active caspase-6 in complex with Ac-VEID-CHO inhibitor== | ||
| - | <StructureSection load='3p4u' size='340' side='right' caption='[[3p4u]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='3p4u' size='340' side='right'caption='[[3p4u]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3p4u]] is a 6 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3p4u]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P4U FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4u OCA], [https://pdbe.org/3p4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p4u RCSB], [https://www.ebi.ac.uk/pdbsum/3p4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p4u ProSAT]</span></td></tr> |
| - | < | + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. |
==See Also== | ==See Also== | ||
| - | *[[Caspase|Caspase]] | + | *[[Caspase 3D structures|Caspase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Caspase-6]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Dominguez | + | [[Category: Large Structures]] |
| - | [[Category: Kiselyov | + | [[Category: Dominguez C]] |
| - | [[Category: Lamers | + | [[Category: Kiselyov A]] |
| - | [[Category: Maillard | + | [[Category: Lamers MBAC]] |
| - | [[Category: Mueller | + | [[Category: Maillard M]] |
| - | [[Category: Munoz | + | [[Category: Mueller I]] |
| - | [[Category: Ritchie | + | [[Category: Munoz I]] |
| - | + | [[Category: Ritchie AJ]] | |
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Current revision
Crystal structure of active caspase-6 in complex with Ac-VEID-CHO inhibitor
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