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1pxv
From Proteopedia
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==The staphostatin-staphopain complex: a forward binding inhibitor in complex with its target cysteine protease== | ==The staphostatin-staphopain complex: a forward binding inhibitor in complex with its target cysteine protease== | ||
| - | <StructureSection load='1pxv' size='340' side='right' caption='[[1pxv]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='1pxv' size='340' side='right'caption='[[1pxv]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1pxv]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1pxv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PXV FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAI:GUANIDINE'>GAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxv OCA], [https://pdbe.org/1pxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pxv RCSB], [https://www.ebi.ac.uk/pdbsum/1pxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pxv ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SSPB_STAAU SSPB_STAAU] Cysteine protease able to degrade elastin, fibrogen, fibronectin and kininogen. Exhibits a strong preference for substrates where arginine is preceded by a hydrophobic amino acid. Promotes detachment of primary human keratinocytes. Along with other extracellular proteases is involved in colonization and infection of human tissues (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1pxv" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Proteinase 3D structures|Proteinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
| - | [[Category: Bochtler | + | [[Category: Bochtler M]] |
| - | [[Category: Dubin | + | [[Category: Dubin A]] |
| - | [[Category: Filipek | + | [[Category: Filipek R]] |
| - | [[Category: Gruca | + | [[Category: Gruca M]] |
| - | [[Category: Oleksy | + | [[Category: Oleksy A]] |
| - | [[Category: Potempa | + | [[Category: Potempa J]] |
| - | [[Category: Rzychon | + | [[Category: Rzychon M]] |
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Current revision
The staphostatin-staphopain complex: a forward binding inhibitor in complex with its target cysteine protease
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