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3ld1
From Proteopedia
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==Crystal Structure of IBV Nsp2a== | ==Crystal Structure of IBV Nsp2a== | ||
| - | <StructureSection load='3ld1' size='340' side='right' caption='[[3ld1]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3ld1' size='340' side='right'caption='[[3ld1]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ld1]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ld1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_infectious_bronchitis_virus_(strain_M41) Avian infectious bronchitis virus (strain M41)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LD1 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.498Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ld1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ld1 OCA], [https://pdbe.org/3ld1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ld1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ld1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ld1 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/R1A_IBVM R1A_IBVM] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). The peptide p16 might be involved in the EGF signaling pathway (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity). |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Bartlam | + | [[Category: Bartlam M]] |
| - | [[Category: Chen | + | [[Category: Chen C]] |
| - | [[Category: Cong | + | [[Category: Cong L]] |
| - | [[Category: Fu | + | [[Category: Fu J]] |
| - | [[Category: Rao | + | [[Category: Rao Z]] |
| - | [[Category: Tang | + | [[Category: Tang H]] |
| - | [[Category: Wei | + | [[Category: Wei L]] |
| - | [[Category: Xu | + | [[Category: Xu Y]] |
| - | [[Category: Yang | + | [[Category: Yang A]] |
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Current revision
Crystal Structure of IBV Nsp2a
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