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| - | [[Image:2cmz.gif|left|200px]] | + | #REDIRECT [[5i2m]] This PDB entry is obsolete and replaced by 5i2m |
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| - | {{Structure
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| - | |PDB= 2cmz |SIZE=350|CAPTION= <scene name='initialview01'>2cmz</scene>, resolution 2.40Å
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| - | |SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+C'>AC1</scene>
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| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>
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| - | |ACTIVITY=
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| - | |GENE=
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| - | }}
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| - | '''CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACIDIC CONFORMATION'''
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| - | ==Overview==
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| - | The vesicular stomatitis virus has an atypical membrane fusion glycoprotein (G) exhibiting a pH-dependent equilibrium between two forms at the virus surface. Membrane fusion is triggered during the transition from the high- to low-pH form. The structure of G in its low-pH form shows the classic hairpin conformation observed in all other fusion proteins in their postfusion conformation, in spite of a novel fold combining features of fusion proteins from classes I and II. The structure provides a framework for understanding the reversibility of the G conformational change. Unexpectedly, G is homologous to gB of herpesviruses, which raises important questions on viral evolution.
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| - | ==About this Structure==
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| - | 2CMZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMZ OCA].
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| - | ==Reference==
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| - | Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G., Roche S, Bressanelli S, Rey FA, Gaudin Y, Science. 2006 Jul 14;313(5784):187-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16840692 16840692]
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| - | [[Category: Single protein]]
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| - | [[Category: Vesicular stomatitis indiana virus]]
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| - | [[Category: Bressanelli, S.]]
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| - | [[Category: Roche, S.]]
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| - | [[Category: CA]]
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| - | [[Category: PE4]]
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| - | [[Category: envelope protein]]
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| - | [[Category: glycoprotein]]
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| - | [[Category: lipoprotein]]
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| - | [[Category: membrane]]
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| - | [[Category: membrane protein]]
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| - | [[Category: transmembrane]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:17:28 2008''
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