1bv1

<StructureSection load='1bv1' size='340' side='right' caption='[[1bv1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[1bv1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BV1 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BET V 1 1.2801 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3505 Betula pendula])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bv1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bv1 RCSB], [http://www.ebi.ac.uk/pdbsum/1bv1 PDBsum]</span></td></tr>

[[http://www.uniprot.org/uniprot/BEV1A_BETVE BEV1A_BETVE]] May be a general steroid carrier protein (By similarity).

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bv/1bv1_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].

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== Publication Abstract from PubMed ==

The three-dimensional structure of the major birch pollen allergen, the 17,500 M(r) acidic protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the crystalline state by X-ray diffraction and in solution by nuclear magnetic resonance (NMR) spectroscopy. This is the first experimentally determined structure of a clinically important inhalant major allergen, estimated to cause allergy in 5-10 million individuals worldwide. The structure shows three regions on the molecular surface predicted to harbour cross-reactive B-cell epitopes which provide a structural basis for the allergic symptoms that birch pollen allergic patients show when they encounter pollens from related trees such as hazel, alder and hornbeam. The structure also shows an unusual feature, a 30 A-long forked cavity that penetrates the entire protein.

X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy.,Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD Nat Struct Biol. 1996 Dec;3(12):1040-5. PMID:8946858<ref>PMID:8946858</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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==See Also==

*[[PYR/PYL/RCAR family of ABA receptors|PYR/PYL/RCAR family of ABA receptors]]

== References ==

<references/>

[[Category: Gajhede, M]]

[[Category: Ipsen, H]]

[[Category: Joostvan, R J]]

[[Category: Larson, J N]]

[[Category: Lowenstein, H]]

[[Category: Osmark, P]]

[[Category: Poulsen, F M]]

[[Category: Schou, C]]

[[Category: Spangfort, M D]]

[[Category: Pathogenesis-related protein]]