2e8p
From Proteopedia
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==Solution structure of the N-terminal SAM-domain of E74-like factor 3== | ==Solution structure of the N-terminal SAM-domain of E74-like factor 3== | ||
| - | <StructureSection load='2e8p' size='340' side='right' caption='[[2e8p | + | <StructureSection load='2e8p' size='340' side='right'caption='[[2e8p]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2e8p]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2e8p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E8P FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e8p OCA], [https://pdbe.org/2e8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e8p RCSB], [https://www.ebi.ac.uk/pdbsum/2e8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e8p ProSAT], [https://www.topsan.org/Proteins/RSGI/2e8p TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ELF3_HUMAN ELF3_HUMAN] Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).<ref>PMID:9234700</ref> <ref>PMID:9336459</ref> <ref>PMID:9129154</ref> <ref>PMID:9395241</ref> <ref>PMID:9417054</ref> <ref>PMID:10391676</ref> <ref>PMID:10644990</ref> <ref>PMID:10773884</ref> <ref>PMID:11036073</ref> <ref>PMID:11313868</ref> <ref>PMID:12713734</ref> <ref>PMID:12414801</ref> <ref>PMID:12624109</ref> <ref>PMID:12682075</ref> <ref>PMID:14715662</ref> <ref>PMID:15075319</ref> <ref>PMID:15169914</ref> <ref>PMID:14767472</ref> <ref>PMID:15794755</ref> <ref>PMID:16307850</ref> <ref>PMID:17060315</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/2e8p_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/2e8p_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e8p ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Goroncy AK]] |
| - | [[Category: | + | [[Category: Harada T]] |
| - | [[Category: | + | [[Category: Kigawa T]] |
| - | [[Category: | + | [[Category: Koshiba S]] |
| - | [[Category: Sato | + | [[Category: Sato M]] |
| - | [[Category: Watanabe | + | [[Category: Watanabe S]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
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Current revision
Solution structure of the N-terminal SAM-domain of E74-like factor 3
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Categories: Homo sapiens | Large Structures | Goroncy AK | Harada T | Kigawa T | Koshiba S | Sato M | Watanabe S | Yokoyama S
