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3rgv

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A single TCR bound to MHCI and MHC II reveals switchable TCR conformers

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Retrieved from "http://52.214.119.220/wiki/index.php/3rgv"

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 ==A single TCR bound to MHCI and MHC II reveals switchable TCR conformers==
-<StructureSection load='3rgv' size='340' side='right' caption='[[3rgv]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+<StructureSection load='3rgv' size='340' side='right'caption='[[3rgv]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3rgv]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RGV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3rgv]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RGV FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-K1, H2-K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rgv RCSB], [http://www.ebi.ac.uk/pdbsum/3rgv PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgv OCA], [https://pdbe.org/3rgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rgv RCSB], [https://www.ebi.ac.uk/pdbsum/3rgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rgv ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[http://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE]] Involved in the presentation of foreign antigens to the immune system.
+[https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE] Involved in the presentation of foreign antigens to the immune system.
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-Major histocompatibility complex class I (MHCI) and MHCII proteins differ in structure and sequence. To understand how T cell receptors (TCRs) can use the same set of variable regions to bind both proteins, we have presented a comparison of a single TCR bound to both MHCI and MHCII ligands. The TCR adopts similar orientations on both ligands with TCR amino acids thought to be evolutionarily conserved for MHC interaction occupying similar positions on the MHCI and MHCII helices. However, the TCR antigen-binding loops use different conformations when interacting with each ligand. Most importantly, we observed alternate TCR core conformations. When bound to MHCI, but not MHCII, Valpha disengages from the Jalpha beta strand, switching Valpha's position relative to Vbeta. In several other structures, either Valpha or Vbeta undergoes this same modification. Thus, both TCR V-domains can switch among alternate conformations, perhaps extending their ability to react with different MHC-peptide ligands.
-A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers.,Yin L, Huseby E, Scott-Browne J, Rubtsova K, Pinilla C, Crawford F, Marrack P, Dai S, Kappler JW Immunity. 2011 Jun 15. PMID:21683626<ref>PMID:21683626</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
 ==See Also==
-*[[Beta-2 microglobulin|Beta-2 microglobulin]]
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-== References ==
-<references/>
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Crawford, F]]
+[[Category: Crawford F]]
-[[Category: Dai, S]]
+[[Category: Dai S]]
-[[Category: Huseby, E]]
+[[Category: Huseby E]]
-[[Category: Kappler, J W]]
+[[Category: Kappler JW]]
-[[Category: Marrack, P]]
+[[Category: Marrack P]]
-[[Category: Pinilla, C]]
+[[Category: Pinilla C]]
-[[Category: Rubtsova, K]]
+[[Category: Rubtsova K]]
-[[Category: Scott-Browne, J]]
+[[Category: Scott-Browne J]]
-[[Category: Yin, L]]
+[[Category: Yin L]]
-[[Category: Immune system]]
-[[Category: Mhc]]
-[[Category: Mhc class i]]
-[[Category: Tcr]]

3rgv

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A single TCR bound to MHCI and MHC II reveals switchable TCR conformers

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