2jp2

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==Solution structure and resonance assignment of the N-terminal EVH1 domain from the human Spred2 protein (Sprouty-related protein with EVH1 domain isoform 2)==
==Solution structure and resonance assignment of the N-terminal EVH1 domain from the human Spred2 protein (Sprouty-related protein with EVH1 domain isoform 2)==
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<StructureSection load='2jp2' size='340' side='right' caption='[[2jp2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2jp2' size='340' side='right'caption='[[2jp2]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jp2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JP2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jp2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JP2 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPRED2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jp2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jp2 RCSB], [http://www.ebi.ac.uk/pdbsum/2jp2 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jp2 OCA], [https://pdbe.org/2jp2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jp2 RCSB], [https://www.ebi.ac.uk/pdbsum/2jp2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jp2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SPRE2_HUMAN SPRE2_HUMAN]] Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.
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[https://www.uniprot.org/uniprot/SPRE2_HUMAN SPRE2_HUMAN] Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/2jp2_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/2jp2_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jp2 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C]]
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[[Category: Large Structures]]
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[[Category: Ball, L J]]
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[[Category: Arrowsmith C]]
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[[Category: Edwards, A]]
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[[Category: Ball LJ]]
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[[Category: Fossi, M]]
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[[Category: Edwards A]]
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[[Category: Jarchau, T]]
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[[Category: Fossi M]]
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[[Category: Lemak, A]]
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[[Category: Jarchau T]]
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[[Category: Oschkinat, H]]
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[[Category: Lemak A]]
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[[Category: Structural genomic]]
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[[Category: Oschkinat H]]
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[[Category: Sundstrom, M]]
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[[Category: Sundstrom M]]
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[[Category: Walter, U]]
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[[Category: Walter U]]
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[[Category: Wiegelt, J]]
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[[Category: Wiegelt J]]
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[[Category: Zimmermann, J]]
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[[Category: Zimmermann J]]
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[[Category: Evh1 domain]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Solution structure]]
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Current revision

Solution structure and resonance assignment of the N-terminal EVH1 domain from the human Spred2 protein (Sprouty-related protein with EVH1 domain isoform 2)

PDB ID 2jp2

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