This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4acu
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Aminoimidazoles as BACE-1 Inhibitors. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 14== | ==Aminoimidazoles as BACE-1 Inhibitors. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 14== | ||
| - | <StructureSection load='4acu' size='340' side='right' caption='[[4acu]], [[Resolution|resolution]] 1.75Å' scene=''> | + | <StructureSection load='4acu' size='340' side='right'caption='[[4acu]], [[Resolution|resolution]] 1.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4acu]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4acu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ACU FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=QN7:(8S)-3,3-DIFLUORO-8-(2-FLUORO-3-METHOXYBIPHENYL-3-YL)-8-PYRIDIN-4-YL-2,3,4,8-TETRAHYDROIMIDAZO[1,5-A]PYRIMIDIN-6-AMINE'>QN7</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=QN7:(8S)-3,3-DIFLUORO-8-(2-FLUORO-3-METHOXYBIPHENYL-3-YL)-8-PYRIDIN-4-YL-2,3,4,8-TETRAHYDROIMIDAZO[1,5-A]PYRIMIDIN-6-AMINE'>QN7</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4acu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acu OCA], [https://pdbe.org/4acu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4acu RCSB], [https://www.ebi.ac.uk/pdbsum/4acu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4acu ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
==See Also== | ==See Also== | ||
| - | *[[Beta secretase|Beta secretase]] | + | *[[Beta secretase 3D structures|Beta secretase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
| Line 26: | Line 18: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Berg | + | [[Category: Berg S]] |
| - | [[Category: Ek | + | [[Category: Ek M]] |
| - | [[Category: Falting | + | [[Category: Falting J]] |
| - | [[Category: Georgievska | + | [[Category: Georgievska B]] |
| - | [[Category: Gustavsson | + | [[Category: Gustavsson S]] |
| - | [[Category: Holenz | + | [[Category: Holenz J]] |
| - | [[Category: Kihlstrom | + | [[Category: Kihlstrom J]] |
| - | [[Category: Kolmodin | + | [[Category: Kolmodin K]] |
| - | [[Category: Lindstrom | + | [[Category: Lindstrom J]] |
| - | [[Category: Neelissen | + | [[Category: Neelissen J]] |
| - | [[Category: Olsson | + | [[Category: Olsson LL]] |
| - | [[Category: Plobeck | + | [[Category: Plobeck N]] |
| - | [[Category: Rotticci | + | [[Category: Rotticci D]] |
| - | [[Category: Sehgelmeble | + | [[Category: Sehgelmeble F]] |
| - | [[Category: Sundstrom | + | [[Category: Sundstrom M]] |
| - | [[Category: Swahn | + | [[Category: Swahn B]] |
| - | [[Category: | + | [[Category: Von Berg S]] |
| - | + | ||
| - | + | ||
Current revision
Aminoimidazoles as BACE-1 Inhibitors. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 14
| |||||||||||
Categories: Homo sapiens | Large Structures | Berg S | Ek M | Falting J | Georgievska B | Gustavsson S | Holenz J | Kihlstrom J | Kolmodin K | Lindstrom J | Neelissen J | Olsson LL | Plobeck N | Rotticci D | Sehgelmeble F | Sundstrom M | Swahn B | Von Berg S
