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4hhf

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==Crystal Structure of chemically synthesized scorpion alpha-toxin OD1==
==Crystal Structure of chemically synthesized scorpion alpha-toxin OD1==
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<StructureSection load='4hhf' size='340' side='right' caption='[[4hhf]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4hhf' size='340' side='right'caption='[[4hhf]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hhf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HHF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hhf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Odontobuthus_doriae Odontobuthus doriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HHF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hhf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hhf RCSB], [http://www.ebi.ac.uk/pdbsum/4hhf PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hhf OCA], [https://pdbe.org/4hhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hhf RCSB], [https://www.ebi.ac.uk/pdbsum/4hhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hhf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SCX1_ODODO SCX1_ODODO]] Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Mammalian sodium channels Nav1.5/SCN2A (only at micromolar concentrations), Nav1.7/SCN9A (EC(50)=4.5 nM) and insect sodium channel para/tipE (EC(50)=80 nM) are affected by this toxin, whereas mammalian sodium channels Nav1.2/SCN2A, Nav1.3/SCN3A, and Nav1.8/SCN10A are unaffected by high concentrations.<ref>PMID:16038905</ref> <ref>PMID:16641312</ref>
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[https://www.uniprot.org/uniprot/SCX1_ODODO SCX1_ODODO] Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Mammalian sodium channels Nav1.5/SCN2A (only at micromolar concentrations), Nav1.7/SCN9A (EC(50)=4.5 nM) and insect sodium channel para/tipE (EC(50)=80 nM) are affected by this toxin, whereas mammalian sodium channels Nav1.2/SCN2A, Nav1.3/SCN3A, and Nav1.8/SCN10A are unaffected by high concentrations.<ref>PMID:16038905</ref> <ref>PMID:16641312</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4hhf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Hemolysin 3D structures|Hemolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Alewood, P F]]
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[[Category: Large Structures]]
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[[Category: Durek, T]]
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[[Category: Odontobuthus doriae]]
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[[Category: Lewis, R J]]
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[[Category: Alewood PF]]
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[[Category: Wang, C I.A]]
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[[Category: Durek T]]
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[[Category: 6]]
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[[Category: Lewis RJ]]
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[[Category: 7]]
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[[Category: Wang CIA]]
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[[Category: C-terminally amidated]]
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[[Category: Gating modulator]]
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[[Category: Inhibition of fast channel inactivation]]
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[[Category: Scorpion long-chain alpha-toxin]]
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[[Category: Toxin]]
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[[Category: Venom gland]]
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[[Category: Voltage-gated sodium channels 1 4]]
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Current revision

Crystal Structure of chemically synthesized scorpion alpha-toxin OD1

PDB ID 4hhf

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