4tpm

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==Crystal structure of 2-(3-alkoxy-1-azetidinyl) quinolines as PDE10A Inhibitors==
==Crystal structure of 2-(3-alkoxy-1-azetidinyl) quinolines as PDE10A Inhibitors==
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<StructureSection load='4tpm' size='340' side='right' caption='[[4tpm]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
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<StructureSection load='4tpm' size='340' side='right'caption='[[4tpm]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tpm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TPM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TPM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tpm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TPM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=35E:[1-(3-{[1-(QUINOLIN-2-YL)AZETIDIN-3-YL]OXY}PYRAZIN-2-YL)PIPERIDIN-4-YL]METHANOL'>35E</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tpp|4tpp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=35E:[1-(3-{[1-(QUINOLIN-2-YL)AZETIDIN-3-YL]OXY}PYRAZIN-2-YL)PIPERIDIN-4-YL]METHANOL'>35E</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tpm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tpm RCSB], [http://www.ebi.ac.uk/pdbsum/4tpm PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tpm OCA], [https://pdbe.org/4tpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tpm RCSB], [https://www.ebi.ac.uk/pdbsum/4tpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tpm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4tpm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chmait, S]]
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[[Category: Homo sapiens]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Large Structures]]
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[[Category: Pde10a]]
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[[Category: Chmait S]]
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[[Category: Quinoline]]
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Current revision

Crystal structure of 2-(3-alkoxy-1-azetidinyl) quinolines as PDE10A Inhibitors

PDB ID 4tpm

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