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3u0x

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==Crystal structure of the B-specific-1,3-galactosyltransferase (GTB) in complex with compound 382==
==Crystal structure of the B-specific-1,3-galactosyltransferase (GTB) in complex with compound 382==
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<StructureSection load='3u0x' size='340' side='right' caption='[[3u0x]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='3u0x' size='340' side='right'caption='[[3u0x]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3u0x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U0X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3u0x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTI:1-(3-PHENYL-1,2,4-THIADIAZOL-5-YL)PIPERAZINE'>GTI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lz7|1lz7]], [[1lzj|1lzj]], [[2rit|2rit]], [[2rix|2rix]], [[2rj8|2rj8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTI:1-(3-PHENYL-1,2,4-THIADIAZOL-5-YL)PIPERAZINE'>GTI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0x OCA], [https://pdbe.org/3u0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0x RCSB], [https://www.ebi.ac.uk/pdbsum/3u0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0x ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fucosylgalactoside_3-alpha-galactosyltransferase Fucosylgalactoside 3-alpha-galactosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.37 2.4.1.37] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u0x RCSB], [http://www.ebi.ac.uk/pdbsum/3u0x PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
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[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
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==See Also==
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*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Jorgensen, R]]
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[[Category: Jorgensen R]]
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[[Category: Palcic, M M]]
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[[Category: Palcic MM]]
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[[Category: Abo]]
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[[Category: Blood group antigen]]
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[[Category: Glycoprotein]]
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[[Category: Glycosyltransferase]]
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[[Category: H-antigen acceptor]]
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[[Category: Manganese]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Open conformation]]
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[[Category: Rossmann fold]]
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[[Category: Transferase gtb]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Udp-gal]]
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Current revision

Crystal structure of the B-specific-1,3-galactosyltransferase (GTB) in complex with compound 382

PDB ID 3u0x

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