4w9q

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==The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-5-ethyl-3,10-diazabicyclo[4.3.1]decan-2-one==
==The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-5-ethyl-3,10-diazabicyclo[4.3.1]decan-2-one==
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<StructureSection load='4w9q' size='340' side='right' caption='[[4w9q]], [[Resolution|resolution]] 1.08&Aring;' scene=''>
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<StructureSection load='4w9q' size='340' side='right'caption='[[4w9q]], [[Resolution|resolution]] 1.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4w9q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W9Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4w9q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W9Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JP:(1S,5S,6R)-10-[(3,5-DICHLOROPHENYL)SULFONYL]-3-[2-(3,4-DIMETHOXYPHENOXY)ETHYL]-5-ETHYL-3,10-DIAZABICYCLO[4.3.1]DECAN-2-ONE'>3JP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.08&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3JP:(1S,5S,6R)-10-[(3,5-DICHLOROPHENYL)SULFONYL]-3-[2-(3,4-DIMETHOXYPHENOXY)ETHYL]-5-ETHYL-3,10-DIAZABICYCLO[4.3.1]DECAN-2-ONE'>3JP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w9q RCSB], [http://www.ebi.ac.uk/pdbsum/4w9q PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9q OCA], [https://pdbe.org/4w9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w9q RCSB], [https://www.ebi.ac.uk/pdbsum/4w9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
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[https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4w9q" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[FKBP 3D structures|FKBP 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Homo sapiens]]
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[[Category: Bracher, A]]
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[[Category: Large Structures]]
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[[Category: Hausch, F]]
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[[Category: Bracher A]]
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[[Category: Kirschner, K]]
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[[Category: Hausch F]]
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[[Category: Kozany, C]]
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[[Category: Kirschner K]]
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[[Category: Pomplun, S]]
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[[Category: Kozany C]]
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[[Category: Wang, Y]]
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[[Category: Pomplun S]]
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[[Category: Fk-506 binding domain]]
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[[Category: Wang Y]]
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[[Category: Hsp90 cochaperone]]
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[[Category: Immunophiline]]
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[[Category: Isomerase]]
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[[Category: Ligand selectivity]]
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[[Category: Peptidyl-prolyl isomerase]]
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Current revision

The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-5-ethyl-3,10-diazabicyclo[4.3.1]decan-2-one

PDB ID 4w9q

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