4cg8

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==Human choline kinase a1 in complex with compound 14==
==Human choline kinase a1 in complex with compound 14==
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<StructureSection load='4cg8' size='340' side='right' caption='[[4cg8]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='4cg8' size='340' side='right'caption='[[4cg8]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CG8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cg8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CG8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G8S:4-[(4-CHLOROPHENYL)(METHYL)AMINO]-1-{4-[4-(4-{[4-(DIMETHYLAMINO)PYRIDINIUM-1-YL]METHYL}PHENYL)BUTYL]BENZYL}PYRIDINIUM'>G8S</scene>, <scene name='pdbligand=G8V:1-BENZYL-4-(DIMETHYLAMINO)PYRIDINIUM'>G8V</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cg9|4cg9]], [[4cga|4cga]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G8S:4-[(4-CHLOROPHENYL)(METHYL)AMINO]-1-{4-[4-(4-{[4-(DIMETHYLAMINO)PYRIDINIUM-1-YL]METHYL}PHENYL)BUTYL]BENZYL}PYRIDINIUM'>G8S</scene>, <scene name='pdbligand=G8V:1-BENZYL-4-(DIMETHYLAMINO)PYRIDINIUM'>G8V</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cg8 RCSB], [http://www.ebi.ac.uk/pdbsum/4cg8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cg8 OCA], [https://pdbe.org/4cg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cg8 RCSB], [https://www.ebi.ac.uk/pdbsum/4cg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cg8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN]] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
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[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4cg8" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Choline kinase|Choline kinase]]
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*[[Choline kinase 3D structures|Choline kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Conejo-Garcia, A]]
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[[Category: Large Structures]]
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[[Category: Figuerola-Conchas, A]]
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[[Category: Conejo-Garcia A]]
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[[Category: Guadix, A Entrena-]]
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[[Category: Entrena-Guadix A]]
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[[Category: Hurtado-Guerrero, R]]
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[[Category: Figuerola-Conchas A]]
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[[Category: Rubio-Ruiz, B]]
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[[Category: Hurtado-Guerrero R]]
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[[Category: Cancer]]
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[[Category: Rubio-Ruiz B]]
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[[Category: Drug target]]
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[[Category: Transferase]]
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Current revision

Human choline kinase a1 in complex with compound 14

PDB ID 4cg8

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