3sm9

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==Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist==
==Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist==
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<StructureSection load='3sm9' size='340' side='right' caption='[[3sm9]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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<StructureSection load='3sm9' size='340' side='right'caption='[[3sm9]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3sm9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SM9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3sm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SM9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPRC1C, GRM3, MGLUR3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sm9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sm9 RCSB], [http://www.ebi.ac.uk/pdbsum/3sm9 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sm9 OCA], [https://pdbe.org/3sm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sm9 RCSB], [https://www.ebi.ac.uk/pdbsum/3sm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sm9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref>
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[https://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref>
==See Also==
==See Also==
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*[[Metabotropic glutamate receptor|Metabotropic glutamate receptor]]
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*[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Cossar, D]]
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[[Category: Bountra C]]
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[[Category: Crombet, L]]
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[[Category: Cossar D]]
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[[Category: Dobrovetsky, E]]
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[[Category: Crombet L]]
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[[Category: Dong, A]]
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[[Category: Dobrovetsky E]]
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[[Category: Edwards, A M]]
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[[Category: Dong A]]
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[[Category: Khutoreskaya, G]]
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[[Category: Edwards AM]]
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[[Category: Structural genomic]]
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[[Category: Khutoreskaya G]]
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[[Category: Seitova, A]]
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[[Category: Seitova A]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Wernimont, A K]]
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[[Category: Wernimont AK]]
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[[Category: Cell membrane]]
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[[Category: G-protein coupled receptor]]
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[[Category: Glycoprotein]]
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[[Category: Membrane]]
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[[Category: Olfaction]]
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[[Category: Phosphoprotein]]
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[[Category: Receptor]]
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[[Category: Sensory transduction]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Transducer]]
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[[Category: Transmembrane]]
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[[Category: Transmembrane helix]]
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Current revision

Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist

PDB ID 3sm9

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