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2d8j

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[[Image:2d8j.gif|left|200px]]
 
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{{Structure
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==Solution structure of the SH3 domain of Fyn-related kinase==
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|PDB= 2d8j |SIZE=350|CAPTION= <scene name='initialview01'>2d8j</scene>
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<StructureSection load='2d8j' size='340' side='right'caption='[[2d8j]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2d8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D8J FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= FrK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d8j OCA], [https://pdbe.org/2d8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d8j RCSB], [https://www.ebi.ac.uk/pdbsum/2d8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d8j ProSAT], [https://www.topsan.org/Proteins/RSGI/2d8j TOPSAN]</span></td></tr>
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}}
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</table>
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== Function ==
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'''Solution structure of the SH3 domain of Fyn-related kinase'''
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[https://www.uniprot.org/uniprot/FRK_MOUSE FRK_MOUSE] Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2D8J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8J OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/2d8j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d8j ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Hayashi F]]
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[[Category: Transferase]]
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[[Category: Kurosaki C]]
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[[Category: Hayashi, F.]]
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[[Category: Qin XR]]
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[[Category: Kurosaki, C.]]
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[[Category: Yokoyama S]]
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[[Category: Qin, X R.]]
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[[Category: Yoshida M]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yokoyama, S.]]
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[[Category: Yoshida, M.]]
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[[Category: fyn-related kinase]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: sh3 domain]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:24:15 2008''
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Current revision

Solution structure of the SH3 domain of Fyn-related kinase

PDB ID 2d8j

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