3u1y

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==Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections==
==Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections==
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<StructureSection load='3u1y' size='340' side='right' caption='[[3u1y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3u1y' size='340' side='right'caption='[[3u1y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3u1y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U1Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3u1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U1Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=03I:(2R)-N-HYDROXY-2-METHYL-2-(METHYLSULFONYL)-4-{4-[3-(MORPHOLIN-4-YL)PROPOXY]BIPHENYL-4-YL}BUTANAMIDE'>03I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpxC, envA, PA4406 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03I:(2R)-N-HYDROXY-2-METHYL-2-(METHYLSULFONYL)-4-{4-[3-(MORPHOLIN-4-YL)PROPOXY]BIPHENYL-4-YL}BUTANAMIDE'>03I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u1y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u1y RCSB], [http://www.ebi.ac.uk/pdbsum/3u1y PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u1y OCA], [https://pdbe.org/3u1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u1y RCSB], [https://www.ebi.ac.uk/pdbsum/3u1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u1y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
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[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In this paper we present the synthesis and SAR as well as selectivity, pharmacokinetic and infection model data for representative analogs of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid 1a.
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Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections.,Brown MF, Reilly U, Abramite JA, Arcari JT, Oliver R, Barham RA, Che Y, Chen JM, Collantes EM, Chung SW, Desbonnet C, Doty J, Doroski M, Engtrakul JJ, Harris TM, Huband M, Knafels J, Leach KL, Liu S, Marfat A, Marra A, McElroy E, Melnick M, Menard CA, Montgomery JI, Mulllins L, Noe MC, O'Donnell J, Penzien J, Plummer MS, Price LM, Shanmugasundaram V, Thoma C, Uccello D, Warmus J, Wishka DG J Med Chem. 2011 Dec 18. PMID:22175825<ref>PMID:22175825</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
==See Also==
*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
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== References ==
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*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase 3D structures|UDP-3-O-acyl-N-acetylglucosamine deacetylase 3D structures]]
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Abramite, J]]
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[[Category: Abramite J]]
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[[Category: Brown, M]]
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[[Category: Brown M]]
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[[Category: Liu, S]]
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[[Category: Liu S]]
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[[Category: Gram negative]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Lpxc]]
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Current revision

Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections

PDB ID 3u1y

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