2juf
From Proteopedia
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==NMR solution structure of PARC CPH Domain. NESG Target HR3443B/SGC-Toronto== | ==NMR solution structure of PARC CPH Domain. NESG Target HR3443B/SGC-Toronto== | ||
| - | <StructureSection load='2juf' size='340' side='right' caption='[[2juf | + | <StructureSection load='2juf' size='340' side='right'caption='[[2juf]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2juf]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2juf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUF FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juf OCA], [https://pdbe.org/2juf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2juf RCSB], [https://www.ebi.ac.uk/pdbsum/2juf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2juf ProSAT], [https://www.topsan.org/Proteins/NESGC/2juf TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CUL9_HUMAN CUL9_HUMAN] Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).<ref>PMID:12526791</ref> <ref>PMID:17332328</ref> <ref>PMID:24793696</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2juf_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2juf_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2juf ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Dhe-Paganon | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Duan | + | [[Category: Dhe-Paganon S]] |
| - | [[Category: Edwards | + | [[Category: Duan S]] |
| - | [[Category: Karra | + | [[Category: Edwards AM]] |
| - | [[Category: Kaustov | + | [[Category: Karra M]] |
| - | [[Category: Lemak | + | [[Category: Kaustov L]] |
| - | [[Category: Liao | + | [[Category: Lemak S]] |
| - | [[Category: Muhandiram | + | [[Category: Liao JCC]] |
| - | + | [[Category: Muhandiram R]] | |
| - | [[Category: Srisailam | + | [[Category: Srisailam SH]] |
| - | [[Category: Sundstrom | + | [[Category: Sundstrom M]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
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Current revision
NMR solution structure of PARC CPH Domain. NESG Target HR3443B/SGC-Toronto
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Dhe-Paganon S | Duan S | Edwards AM | Karra M | Kaustov L | Lemak S | Liao JCC | Muhandiram R | Srisailam SH | Sundstrom M | Weigelt J
