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2dn8

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==Solution Structure of RSGI RUH-053, an Apo-Biotin Carboxy Carrier Protein from Human Transcarboxylase==
==Solution Structure of RSGI RUH-053, an Apo-Biotin Carboxy Carrier Protein from Human Transcarboxylase==
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<StructureSection load='2dn8' size='340' side='right' caption='[[2dn8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2dn8' size='340' side='right'caption='[[2dn8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2dn8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DN8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2dn8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DN8 FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_carboxylase Acetyl-CoA carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.4.1.2 6.4.1.2] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dn8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dn8 RCSB], [http://www.ebi.ac.uk/pdbsum/2dn8 PDBsum], [http://www.topsan.org/Proteins/RSGI/2dn8 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dn8 OCA], [https://pdbe.org/2dn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dn8 RCSB], [https://www.ebi.ac.uk/pdbsum/2dn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dn8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dn8 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACACB_HUMAN ACACB_HUMAN]] ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
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[https://www.uniprot.org/uniprot/ACACB_HUMAN ACACB_HUMAN] ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dn8_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dn8_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dn8 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Acetyl-CoA carboxylase|Acetyl-CoA carboxylase]]
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*[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acetyl-CoA carboxylase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hayashi, F]]
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[[Category: Large Structures]]
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[[Category: Hirota, H]]
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[[Category: Hayashi F]]
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[[Category: Momen, A Z.M Ruhul]]
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[[Category: Hirota H]]
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[[Category: Structural genomic]]
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[[Category: Ruhul Momen AZM]]
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[[Category: Yokoyama, S]]
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[[Category: Yokoyama S]]
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[[Category: Acetyl coa carboxylase]]
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[[Category: Biotin required enzyme]]
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[[Category: Ligase]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Transcarboxylase]]
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Current revision

Solution Structure of RSGI RUH-053, an Apo-Biotin Carboxy Carrier Protein from Human Transcarboxylase

PDB ID 2dn8

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