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| - | ==Structure of TM1797, a CAS1 protein from Thermotoga maritima==
| + | #REDIRECT [[4xtk]] This PDB entry is obsolete and replaced by 4xtk |
| - | <StructureSection load='3lfx' size='340' side='right' caption='[[3lfx]], [[Resolution|resolution]] 2.70Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[3lfx]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LFX FirstGlance]. <br>
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| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yzs|2yzs]], [[3god|3god]]</td></tr>
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| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SYNTHETIC GENE, TM_1797 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lfx RCSB], [http://www.ebi.ac.uk/pdbsum/3lfx PDBsum]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/Q9X2B7_THEMA Q9X2B7_THEMA]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity).[HAMAP-Rule:MF_01470]
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| - | == Evolutionary Conservation ==
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| - | [[Image:Consurf_key_small.gif|200px|right]]
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| - | Check<jmol>
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| - | <jmolCheckbox>
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| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lf/3lfx_consurf.spt"</scriptWhenChecked>
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| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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| - | <text>to colour the structure by Evolutionary Conservation</text>
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| - | </jmolCheckbox>
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| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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| - | <div style="clear:both"></div>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Thermotoga maritima]]
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| - | [[Category: Beloglazova, N]]
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| - | [[Category: Chang, C]]
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| - | [[Category: Edwards, A]]
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| - | [[Category: Joachimiak, A]]
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| - | [[Category: Structural genomic]]
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| - | [[Category: Petit, P]]
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| - | [[Category: Savchenko, A]]
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| - | [[Category: Skarina, T]]
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| - | [[Category: Cas1]]
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| - | [[Category: Dnase]]
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| - | [[Category: Mcsg]]
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| - | [[Category: Prokaryotic immune system]]
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| - | [[Category: PSI, Protein structure initiative]]
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| - | [[Category: Unknown function]]
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