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3vmt
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==Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a Lipid II analog== | ==Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a Lipid II analog== | ||
| - | <StructureSection load='3vmt' size='340' side='right' caption='[[3vmt]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='3vmt' size='340' side='right'caption='[[3vmt]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3vmt]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3vmt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VMT FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LHI:[(2R,3R,4R,5S,6R)-4-[(2R)-1-[[(2S)-1-[2-[2-[2-[5-[(3AS,4S,6AR)-2-OXIDANYLIDENE-1,3,3A,4,6,6A-HEXAHYDROTHIENO[3,4-D]IMIDAZOL-4-YL]PENTANOYLAMINO]ETHOXY]ETHOXY]ETHYLAMINO]-1-OXIDANYLIDENE-PROPAN-2-YL]AMINO]-1-OXIDANYLIDENE-PROPAN-2-YL]OXY-3-ACETAMIDO-5-[(2S,3R,4R,5R,6R)-3-ACETAMIDO-6-(HYDROXYMETHYL)-4,5-BIS(OXIDANYL)OXAN-2-YL]OXY-6-(HYDROXYMETHYL)OXAN-2-YL]+[OXIDANYL(3,7,11,15,19,23,27,31,35,39,43-UNDECAMETHYLTETRATETRACONTA-2,6,10,14,18,22,26,30,34,38,42-UNDECAENOXY)PHOSPHORYL]+HYDROGEN+PHOSPHATE'>LHI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.299Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LHI:[(2R,3R,4R,5S,6R)-4-[(2R)-1-[[(2S)-1-[2-[2-[2-[5-[(3AS,4S,6AR)-2-OXIDANYLIDENE-1,3,3A,4,6,6A-HEXAHYDROTHIENO[3,4-D]IMIDAZOL-4-YL]PENTANOYLAMINO]ETHOXY]ETHOXY]ETHYLAMINO]-1-OXIDANYLIDENE-PROPAN-2-YL]AMINO]-1-OXIDANYLIDENE-PROPAN-2-YL]OXY-3-ACETAMIDO-5-[(2S,3R,4R,5R,6R)-3-ACETAMIDO-6-(HYDROXYMETHYL)-4,5-BIS(OXIDANYL)OXAN-2-YL]OXY-6-(HYDROXYMETHYL)OXAN-2-YL]+[OXIDANYL(3,7,11,15,19,23,27,31,35,39,43-UNDECAMETHYLTETRATETRACONTA-2,6,10,14,18,22,26,30,34,38,42-UNDECAENOXY)PHOSPHORYL]+HYDROGEN+PHOSPHATE'>LHI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vmt OCA], [https://pdbe.org/3vmt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vmt RCSB], [https://www.ebi.ac.uk/pdbsum/3vmt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vmt ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/MGT_STAAM MGT_STAAM] Involved in the biosynthesis of cell wall peptidoglycan. Responsible for the elongation of the glycan strands using lipid-linked disaccharide-pentapeptide as the substrate (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 18: | Line 18: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3vmt" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Glycosyltransferase|Glycosyltransferase]] | + | *[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Staphylococcus aureus subsp. aureus | + | [[Category: Large Structures]] |
| - | [[Category: Cheng | + | [[Category: Staphylococcus aureus subsp. aureus Mu50]] |
| - | [[Category: Cheng | + | [[Category: Cheng TJR]] |
| - | [[Category: Huang | + | [[Category: Cheng WC]] |
| - | [[Category: Lin | + | [[Category: Huang CY]] |
| - | [[Category: Ma | + | [[Category: Lin LY]] |
| - | [[Category: Shih | + | [[Category: Ma C]] |
| - | [[Category: Tien | + | [[Category: Shih HW]] |
| - | [[Category: Wong | + | [[Category: Tien YW]] |
| - | + | [[Category: Wong CH]] | |
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Current revision
Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a Lipid II analog
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