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4gc9

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==Crystal structure of murine TFB1M in complex with SAM==
==Crystal structure of murine TFB1M in complex with SAM==
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<StructureSection load='4gc9' size='340' side='right' caption='[[4gc9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4gc9' size='340' side='right'caption='[[4gc9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GC9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gc9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GC9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.103&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gc5|4gc5]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gc9 OCA], [https://pdbe.org/4gc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gc9 RCSB], [https://www.ebi.ac.uk/pdbsum/4gc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gc9 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tfb1m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gc9 RCSB], [http://www.ebi.ac.uk/pdbsum/4gc9 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TFB1M_MOUSE TFB1M_MOUSE]] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity).
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[https://www.uniprot.org/uniprot/TFB1M_MOUSE TFB1M_MOUSE] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4gc9" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Garcia-Diaz, M]]
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[[Category: Garcia-Diaz M]]
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[[Category: Guja, K E]]
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[[Category: Guja KE]]
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[[Category: Hambardjieva, E]]
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[[Category: Hambardjieva E]]
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[[Category: Karzai, A W]]
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[[Category: Karzai AW]]
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[[Category: Mejia, E]]
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[[Category: Mejia E]]
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[[Category: Shi, H]]
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[[Category: Shi H]]
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[[Category: Venkataraman, K]]
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[[Category: Venkataraman K]]
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[[Category: Yakubovskaya, E]]
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[[Category: Yakubovskaya E]]
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[[Category: Methylation]]
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[[Category: Methyltransferase fold]]
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[[Category: Mitochondria]]
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[[Category: Rrna methyltransferase]]
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[[Category: S-adenosyl-l-methionine]]
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[[Category: Transferase]]
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Current revision

Crystal structure of murine TFB1M in complex with SAM

PDB ID 4gc9

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