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4kvs

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==Crystal Structure of Prochlorococcus marinus aldehyde-deformylating oxygenase (mutant A134F)==
==Crystal Structure of Prochlorococcus marinus aldehyde-deformylating oxygenase (mutant A134F)==
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<StructureSection load='4kvs' size='340' side='right' caption='[[4kvs]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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<StructureSection load='4kvs' size='340' side='right'caption='[[4kvs]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Prochlorococcus_marinus_str._mit_9313 Prochlorococcus marinus str. mit 9313]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KVS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kvs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Prochlorococcus_marinus_str._MIT_9313 Prochlorococcus marinus str. MIT 9313]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KVS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6NA:HEXANOIC+ACID'>6NA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2oc5|2oc5]], [[4kvq|4kvq]], [[4kvr|4kvr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6NA:HEXANOIC+ACID'>6NA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PMT_1231 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=74547 Prochlorococcus marinus str. MIT 9313])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kvs OCA], [https://pdbe.org/4kvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kvs RCSB], [https://www.ebi.ac.uk/pdbsum/4kvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kvs ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Octadecanal_decarbonylase Octadecanal decarbonylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.99.5 4.1.99.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kvs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kvs RCSB], [http://www.ebi.ac.uk/pdbsum/4kvs PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ALDEC_PROMM ALDEC_PROMM]] Catalyzes the decarbonylation of fatty aldehydes to alkanes. Requires the presence of ferredoxin, ferredoxin reductase and NADPH for in vitro decarbonylase activity (By similarity). Involved in the biosynthesis of alkanes, mainly heptadecane and pentadecane.<ref>PMID:20671186</ref>
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[https://www.uniprot.org/uniprot/ALDEC_PROMM ALDEC_PROMM] Catalyzes the decarbonylation of fatty aldehydes to alkanes. Requires the presence of ferredoxin, ferredoxin reductase and NADPH for in vitro decarbonylase activity (By similarity). Involved in the biosynthesis of alkanes, mainly heptadecane and pentadecane.<ref>PMID:20671186</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Biocatalytic propane production: structure-based engineering of aldehyde-deformylating oxygenase improves specificity for short- and medium-chain-length aldehydes and enhances the propane generation in whole-cell biotransformations. This presents new opportunities for developing biocatalytic modules for the production of volatile "drop-in" biofuels.
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Production of Propane and Other Short-Chain Alkanes by Structure-Based Engineering of Ligand Specificity in Aldehyde-Deformylating Oxygenase.,Khara B, Menon N, Levy C, Mansell D, Das D, Marsh EN, Leys D, Scrutton NS Chembiochem. 2013 Jun 11. doi: 10.1002/cbic.201300307. PMID:23757044<ref>PMID:23757044</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Octadecanal decarbonylase]]
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[[Category: Large Structures]]
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[[Category: Prochlorococcus marinus str. mit 9313]]
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[[Category: Prochlorococcus marinus str. MIT 9313]]
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[[Category: Das, D]]
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[[Category: Das D]]
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[[Category: Khara, B]]
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[[Category: Khara B]]
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[[Category: Levy, C W]]
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[[Category: Levy CW]]
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[[Category: Leys, D]]
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[[Category: Leys D]]
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[[Category: Mansell, D]]
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[[Category: Mansell D]]
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[[Category: Marsh, E N.G]]
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[[Category: Marsh ENG]]
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[[Category: Menon, N]]
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[[Category: Menon N]]
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[[Category: Scrutton, N S]]
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[[Category: Scrutton NS]]
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[[Category: Aldehyde-deformylating oxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: Propane production]]
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Current revision

Crystal Structure of Prochlorococcus marinus aldehyde-deformylating oxygenase (mutant A134F)

PDB ID 4kvs

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