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2yp4

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==Haemagglutinin of 2004 Human H3N2 Virus in Complex with Human Receptor Analogue LSTc==
==Haemagglutinin of 2004 Human H3N2 Virus in Complex with Human Receptor Analogue LSTc==
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<StructureSection load='2yp4' size='340' side='right' caption='[[2yp4]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='2yp4' size='340' side='right'caption='[[2yp4]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yp4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YP4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yp4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YP4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yp2|2yp2]], [[2yp3|2yp3]], [[2yp5|2yp5]], [[2yp7|2yp7]], [[2yp8|2yp8]], [[2yp9|2yp9]], [[2ypg|2ypg]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yp4 OCA], [https://pdbe.org/2yp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yp4 RCSB], [https://www.ebi.ac.uk/pdbsum/2yp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yp4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yp4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yp4 RCSB], [http://www.ebi.ac.uk/pdbsum/2yp4 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0FCI1_9INFA A0FCI1_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386]
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[https://www.uniprot.org/uniprot/K7N5L2_9INFA K7N5L2_9INFA]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2yp4" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Influenza a virus]]
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[[Category: Influenza A virus]]
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[[Category: Christodoulou, E]]
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[[Category: Large Structures]]
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[[Category: Coombs, P J]]
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[[Category: Christodoulou E]]
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[[Category: Daniels, R S]]
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[[Category: Coombs PJ]]
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[[Category: Gamblin, S J]]
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[[Category: Daniels RS]]
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[[Category: Hay, A J]]
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[[Category: Gamblin SJ]]
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[[Category: Lin, Y P]]
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[[Category: Hay AJ]]
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[[Category: Liu, J]]
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[[Category: Lin YP]]
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[[Category: Martin, S R]]
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[[Category: Liu J]]
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[[Category: McCauley, J W]]
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[[Category: Martin SR]]
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[[Category: Skehel, J J]]
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[[Category: McCauley JW]]
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[[Category: Vachieri, S G]]
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[[Category: Skehel JJ]]
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[[Category: Walker, P A]]
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[[Category: Vachieri SG]]
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[[Category: Wharton, S A]]
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[[Category: Walker PA]]
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[[Category: Xiong, X]]
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[[Category: Wharton SA]]
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[[Category: Glycoprotein]]
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[[Category: Xiong X]]
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[[Category: Membrane fusion]]
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[[Category: Receptor binding]]
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[[Category: Viral protein]]
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Current revision

Haemagglutinin of 2004 Human H3N2 Virus in Complex with Human Receptor Analogue LSTc

PDB ID 2yp4

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