4jt3
From Proteopedia
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==Crystal Structure of TTK kinase domain with an inhibitor: 400740== | ==Crystal Structure of TTK kinase domain with an inhibitor: 400740== | ||
| - | <StructureSection load='4jt3' size='340' side='right' caption='[[4jt3]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='4jt3' size='340' side='right'caption='[[4jt3]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4jt3]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4jt3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JT3 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PH:2-PHENYL-N-[3-(3-SULFAMOYLPHENYL)-2H-INDAZOL-5-YL]ACETAMIDE'>1PH</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PH:2-PHENYL-N-[3-(3-SULFAMOYLPHENYL)-2H-INDAZOL-5-YL]ACETAMIDE'>1PH</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jt3 OCA], [https://pdbe.org/4jt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jt3 RCSB], [https://www.ebi.ac.uk/pdbsum/4jt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jt3 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> |
==See Also== | ==See Also== | ||
| - | *[[Dual specificity protein kinase|Dual specificity protein kinase]] | + | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Awrey | + | [[Category: Awrey DE]] |
| - | [[Category: Chirgadze | + | [[Category: Chirgadze NY]] |
| - | [[Category: Feher | + | [[Category: Feher M]] |
| - | [[Category: Harris-Brandts | + | [[Category: Harris-Brandts M]] |
| - | [[Category: Qiu | + | [[Category: Qiu W]] |
| - | + | ||
Current revision
Crystal Structure of TTK kinase domain with an inhibitor: 400740
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