This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2dn7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:44, 29 May 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2dn7.jpg|left|200px]]
 
-
{{Structure
+
==Solution structures of the 6th fn3 domain of human receptor-type tyrosine-protein phosphatase F==
-
|PDB= 2dn7 |SIZE=350|CAPTION= <scene name='initialview01'>2dn7</scene>
+
<StructureSection load='2dn7' size='340' side='right'caption='[[2dn7]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[2dn7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DN7 FirstGlance]. <br>
-
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE= PTPRF, LAR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dn7 OCA], [https://pdbe.org/2dn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dn7 RCSB], [https://www.ebi.ac.uk/pdbsum/2dn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dn7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dn7 TOPSAN]</span></td></tr>
-
}}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PTPRF_HUMAN PTPRF_HUMAN] Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).<ref>PMID:10338209</ref> The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.<ref>PMID:10338209</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dn7_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dn7 ConSurf].
 +
<div style="clear:both"></div>
-
'''Solution structures of the 6th fn3 domain of human receptor-type tyrosine-protein phosphatase F'''
+
==See Also==
-
 
+
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-
 
+
== References ==
-
==Disease==
+
<references/>
-
Known disease associated with this structure: Leukemia, acute myeloid OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604763 604763]]
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2DN7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DN7 OCA].
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Protein-tyrosine-phosphatase]]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Inoue M]]
-
[[Category: Inoue, M.]]
+
[[Category: Kigawa T]]
-
[[Category: Kigawa, T.]]
+
[[Category: Koshiba S]]
-
[[Category: Koshiba, S.]]
+
[[Category: Sato M]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Tochio N]]
-
[[Category: Sato, M.]]
+
[[Category: Yokoyama S]]
-
[[Category: Tochio, N.]]
+
-
[[Category: Yokoyama, S.]]
+
-
[[Category: lar protein]]
+
-
[[Category: leukocyte antigen related]]
+
-
[[Category: national project on protein structural and functional analyse]]
+
-
[[Category: nppsfa]]
+
-
[[Category: riken structural genomics/proteomics initiative]]
+
-
[[Category: rsgi]]
+
-
[[Category: structural genomic]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:29:12 2008''
+

Current revision

Solution structures of the 6th fn3 domain of human receptor-type tyrosine-protein phosphatase F

PDB ID 2dn7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2dn7"
Personal tools