3km8
From Proteopedia
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==Crystal structuore of adenosine deaminase from mus musculus complexed with 9-deazainosine== | ==Crystal structuore of adenosine deaminase from mus musculus complexed with 9-deazainosine== | ||
| - | <StructureSection load='3km8' size='340' side='right' caption='[[3km8]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='3km8' size='340' side='right'caption='[[3km8]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3km8]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3km8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KM8 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9DI:9-DEAZAINOSINE'>9DI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3km8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3km8 OCA], [https://pdbe.org/3km8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3km8 RCSB], [https://www.ebi.ac.uk/pdbsum/3km8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3km8 ProSAT]</span></td></tr> |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ADA_MOUSE ADA_MOUSE] Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). |
==See Also== | ==See Also== | ||
| - | *[[Adenosine deaminase|Adenosine deaminase]] | + | *[[Adenosine deaminase 3D structures|Adenosine deaminase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Fan | + | [[Category: Fan X]] |
| - | [[Category: Gao | + | [[Category: Gao Y]] |
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Current revision
Crystal structuore of adenosine deaminase from mus musculus complexed with 9-deazainosine
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