3eml

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==The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.==
==The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.==
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<StructureSection load='3eml' size='340' side='right' caption='[[3eml]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='3eml' size='340' side='right'caption='[[3eml]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3eml]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EML FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3eml]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EML FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene>, <scene name='pdbligand=ZMA:4-{2-[(7-AMINO-2-FURAN-2-YL[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZIN-5-YL)AMINO]ETHYL}PHENOL'>ZMA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eml RCSB], [http://www.ebi.ac.uk/pdbsum/3eml PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene>, <scene name='pdbligand=ZMA:4-{2-[(7-AMINO-2-FURAN-2-YL[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZIN-5-YL)AMINO]ETHYL}PHENOL'>ZMA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eml OCA], [https://pdbe.org/3eml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eml RCSB], [https://www.ebi.ac.uk/pdbsum/3eml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eml ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN]] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/3eml_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/3eml_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eml ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3eml" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Adenosine A2A receptor|Adenosine A2A receptor]]
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*[[Adenosine A2A receptor 3D structures|Adenosine A2A receptor 3D structures]]
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*[[G protein-coupled receptor|G protein-coupled receptor]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia virus T4]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]
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[[Category: Large Structures]]
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[[Category: Cherezov, V]]
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[[Category: Cherezov V]]
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[[Category: Chien, E Y.T]]
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[[Category: Chien EYT]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Griffith MT]]
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[[Category: Griffith, M T]]
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[[Category: Hanson MA]]
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[[Category: Hanson, M A]]
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[[Category: Ijzerman AP]]
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[[Category: Ijzerman, A P]]
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[[Category: Jaakola V-P]]
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[[Category: Jaakola, V P]]
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[[Category: Lane JR]]
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[[Category: Lane, J R]]
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[[Category: Stevens RC]]
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[[Category: Stevens, R C]]
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[[Category: Accelerated technologies center for gene to 3d structure]]
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[[Category: Adenosine]]
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[[Category: Atcg3d]]
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[[Category: Caffeine]]
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[[Category: Gpcr]]
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[[Category: Lcp]]
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[[Category: Membrane protein]]
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[[Category: Mesophase]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Receptor]]
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[[Category: Structural genomic]]
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Current revision

The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.

PDB ID 3eml

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