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3hkv
From Proteopedia
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==Human poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide== | ==Human poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide== | ||
| - | <StructureSection load='3hkv' size='340' side='right' caption='[[3hkv]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='3hkv' size='340' side='right'caption='[[3hkv]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3hkv]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3hkv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HKV FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | < | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hkv OCA], [https://pdbe.org/3hkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hkv RCSB], [https://www.ebi.ac.uk/pdbsum/3hkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hkv ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PAR10_HUMAN PAR10_HUMAN] May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.<ref>PMID:15674325</ref> <ref>PMID:16455663</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/3hkv_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/3hkv_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hkv ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]] | + | *[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Berglund | + | [[Category: Berglund H]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Collins | + | [[Category: Collins R]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Flodin | + | [[Category: Flodin S]] |
| - | [[Category: Flores | + | [[Category: Flores A]] |
| - | [[Category: Graslund | + | [[Category: Graslund S]] |
| - | [[Category: Hammarstrom | + | [[Category: Hammarstrom M]] |
| - | [[Category: Johansson | + | [[Category: Johansson A]] |
| - | [[Category: Johansson | + | [[Category: Johansson I]] |
| - | [[Category: Karlberg | + | [[Category: Karlberg T]] |
| - | [[Category: Kotenyova | + | [[Category: Kotenyova T]] |
| - | [[Category: Kotzsch | + | [[Category: Kotzsch A]] |
| - | [[Category: Moche | + | [[Category: Moche M]] |
| - | [[Category: Nielsen | + | [[Category: Nielsen TK]] |
| - | [[Category: Nordlund | + | [[Category: Nordlund P]] |
| - | [[Category: Nyman | + | [[Category: Nyman T]] |
| - | [[Category: Persson | + | [[Category: Persson C]] |
| - | [[Category: Roos | + | [[Category: Roos AK]] |
| - | [[Category: Sagemark | + | [[Category: Sagemark J]] |
| - | [[Category: Schuler | + | [[Category: Schuler H]] |
| - | [[Category: Schutz | + | [[Category: Schutz P]] |
| - | [[Category: Siponen | + | [[Category: Siponen MI]] |
| - | [[Category: Thorsell | + | [[Category: Thorsell AG]] |
| - | [[Category: Tresaugues | + | [[Category: Tresaugues L]] |
| - | [[Category: | + | [[Category: Van Den Berg S]] |
| - | [[Category: | + | [[Category: Weigelt J]] |
| - | [[Category: | + | [[Category: Welin M]] |
| - | [[Category: | + | [[Category: Wisniewska M]] |
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Current revision
Human poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Berglund H | Bountra C | Collins R | Edwards AM | Flodin S | Flores A | Graslund S | Hammarstrom M | Johansson A | Johansson I | Karlberg T | Kotenyova T | Kotzsch A | Moche M | Nielsen TK | Nordlund P | Nyman T | Persson C | Roos AK | Sagemark J | Schuler H | Schutz P | Siponen MI | Thorsell AG | Tresaugues L | Van Den Berg S | Weigelt J | Welin M | Wisniewska M
