4dc2

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==Structure of PKC in Complex with a Substrate Peptide from Par-3==
==Structure of PKC in Complex with a Substrate Peptide from Par-3==
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<StructureSection load='4dc2' size='340' side='right' caption='[[4dc2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4dc2' size='340' side='right'caption='[[4dc2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4dc2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DC2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4dc2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DC2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pkcl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dc2 OCA], [https://pdbe.org/4dc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dc2 RCSB], [https://www.ebi.ac.uk/pdbsum/4dc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dc2 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_kinase_C Protein kinase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.13 2.7.11.13] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dc2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dc2 RCSB], [http://www.ebi.ac.uk/pdbsum/4dc2 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/PARD3_RAT PARD3_RAT]] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Targets the phosphatase PTEN to cell junctions.<ref>PMID:18082612</ref> <ref>PMID:18550519</ref>
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4dc2" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Protein kinase C|Protein kinase C]]
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*[[Protein kinase C 3D structures|Protein kinase C 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein kinase C]]
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[[Category: Rattus norvegicus]]
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[[Category: Shang, Y]]
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[[Category: Shang Y]]
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[[Category: Wang, C]]
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[[Category: Wang C]]
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[[Category: Yu, J]]
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[[Category: Yu J]]
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[[Category: Zhang, M]]
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[[Category: Zhang M]]
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[[Category: Atypical pkc]]
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[[Category: Cell polarity]]
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[[Category: Kinase]]
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[[Category: Par-3]]
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[[Category: Substrate]]
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[[Category: Transferase-transferase substrate complex]]
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Current revision

Structure of PKC in Complex with a Substrate Peptide from Par-3

PDB ID 4dc2

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