4qi9

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==Crystal structure of dihydrofolate reductase from Yersinia pestis complexed with methotrexate==
==Crystal structure of dihydrofolate reductase from Yersinia pestis complexed with methotrexate==
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<StructureSection load='4qi9' size='340' side='right' caption='[[4qi9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4qi9' size='340' side='right'caption='[[4qi9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qi9]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QI9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qi9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_CO92 Yersinia pestis CO92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QI9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.297&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q1h|3q1h]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qi9 OCA], [https://pdbe.org/4qi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qi9 RCSB], [https://www.ebi.ac.uk/pdbsum/4qi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qi9 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qi9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qi9 RCSB], [http://www.ebi.ac.uk/pdbsum/4qi9 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q7CG83_YERPE Q7CG83_YERPE]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
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[https://www.uniprot.org/uniprot/A0A3N4BLI0_YERPE A0A3N4BLI0_YERPE] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[ARBA:ARBA00025067][PIRNR:PIRNR000194]
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dihydrofolate reductase]]
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[[Category: Large Structures]]
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[[Category: Anderson, W F]]
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[[Category: Yersinia pestis CO92]]
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[[Category: Structural genomic]]
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[[Category: Anderson WF]]
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[[Category: Joachimiak, A]]
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[[Category: Joachimiak A]]
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[[Category: Kim, Y]]
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[[Category: Kim Y]]
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[[Category: Makowska-Grzyska, M]]
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[[Category: Makowska-Grzyska M]]
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[[Category: Maltseva, N]]
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[[Category: Maltseva N]]
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[[Category: Mulligan, R]]
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[[Category: Mulligan R]]
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[[Category: Shatsman, S]]
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[[Category: Shatsman S]]
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[[Category: Alpha beta fold]]
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[[Category: Csgid]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Current revision

Crystal structure of dihydrofolate reductase from Yersinia pestis complexed with methotrexate

PDB ID 4qi9

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