4muw

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==Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor==
==Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor==
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<StructureSection load='4muw' size='340' side='right' caption='[[4muw]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
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<StructureSection load='4muw' size='340' side='right'caption='[[4muw]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4muw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MUW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4muw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MUW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2F4:2-{4-[(6,7-DIFLUORO-1H-BENZIMIDAZOL-2-YL)AMINO]PHENOXY}-N-METHYL-3,4-BIPYRIDIN-2-AMINE'>2F4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.639&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2F4:2-{4-[(6,7-DIFLUORO-1H-BENZIMIDAZOL-2-YL)AMINO]PHENOXY}-N-METHYL-3,4-BIPYRIDIN-2-AMINE'>2F4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4muw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4muw RCSB], [http://www.ebi.ac.uk/pdbsum/4muw PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4muw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muw OCA], [https://pdbe.org/4muw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4muw RCSB], [https://www.ebi.ac.uk/pdbsum/4muw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4muw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4muw" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Chmait, S]]
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[[Category: Large Structures]]
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[[Category: Jordan, S]]
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[[Category: Chmait S]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Jordan S]]
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[[Category: Inhibitor]]
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[[Category: Keto-benzimidazole]]
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[[Category: Pde10a]]
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[[Category: Phosphodiesterase 10a]]
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Current revision

Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor

PDB ID 4muw

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