3tgn

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==Crystal Structure of the zinc-dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-bound State==
==Crystal Structure of the zinc-dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-bound State==
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<StructureSection load='3tgn' size='340' side='right' caption='[[3tgn]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3tgn' size='340' side='right'caption='[[3tgn]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tgn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TGN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tgn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_D39 Streptococcus pneumoniae D39]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TGN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">adcR, SPD_2000 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tgn RCSB], [http://www.ebi.ac.uk/pdbsum/3tgn PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgn OCA], [https://pdbe.org/3tgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tgn RCSB], [https://www.ebi.ac.uk/pdbsum/3tgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q04I02_STRP2 Q04I02_STRP2]] Zinc-responsive regulator that acts both as a repressor and as an activator by regulating directly the promoters of its target genes. In the presence of zinc, directly represses the expression of the adcRCBA operon, of genes coding for a group of surface antigen zinc-binding pneumococcal histidine triad proteins (PhtA, PhtB, PhtD and PhtE), and of adcAII. Can also activate expression of adh.<ref>PMID:20804771</ref> <ref>PMID:21603707</ref>
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[https://www.uniprot.org/uniprot/ADCR_STRP2 ADCR_STRP2] Zinc-responsive regulator that acts both as a repressor and as an activator by regulating directly the promoters of its target genes. In the presence of zinc, directly represses the expression of the adcRCBA operon, of genes coding for a group of surface antigen zinc-binding pneumococcal histidine triad proteins (PhtA, PhtB, PhtD and PhtE), and of adcAII. Can also activate expression of adh.<ref>PMID:20804771</ref> <ref>PMID:21603707</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Streptococcus pneumoniae adhesin competence regulator (AdcR), the first metal-dependent member of the multiple antibiotic resistance regulator (MarR) family of proteins, represses the transcription of a high-affinity zinc-specific uptake transporter, a group of surface antigen zinc-binding pneumococcal histidine triad proteins (PhtA, PhtB, PhtD, and PhtE), and an AdcA homologue (AdcAII). The 2.0 A resolution structure of Zn(II)-bound AdcR reveals a highly helical two-fold-symmetric dimer with two distinct metal-binding sites per protomer. Zn(II) is tetrahedrally coordinated by E24, H42, H108, and H112 in what defines the primary sensing site in AdcR. Site 2 is a tetracoordinate site whose function is currently unknown. NMR methyl group perturbation experiments reveal that Zn(II) drives a global change in the structure of apo-AdcR that stabilizes a conformation that is compatible with DNA binding. This co-repression mechanism is unprecedented in MarR transcriptional regulators.
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Crystal Structure of the Zinc-Dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-Bound State.,Guerra AJ, Dann CE, Giedroc DP J Am Chem Soc. 2011 Nov 21. PMID:22085181<ref>PMID:22085181</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Streptococcus pneumoniae]]
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[[Category: Large Structures]]
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[[Category: Giedroc, D P]]
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[[Category: Streptococcus pneumoniae D39]]
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[[Category: Guerra, A J]]
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[[Category: Dann III CE]]
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[[Category: III, C E.Dann]]
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[[Category: Giedroc DP]]
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[[Category: Helix-turn-helix]]
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[[Category: Guerra AJ]]
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[[Category: Transcription]]
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[[Category: Transcriptional regulator]]
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Current revision

Crystal Structure of the zinc-dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-bound State

PDB ID 3tgn

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