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1zv4

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==Structure of the Regulator of G-Protein Signaling 17 (RGSZ2)==
==Structure of the Regulator of G-Protein Signaling 17 (RGSZ2)==
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<StructureSection load='1zv4' size='340' side='right' caption='[[1zv4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='1zv4' size='340' side='right'caption='[[1zv4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1zv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZV4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1zv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZV4 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RGS17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1zv4 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zv4 OCA], [https://pdbe.org/1zv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1zv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zv4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RGS17_HUMAN RGS17_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
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[https://www.uniprot.org/uniprot/RGS17_HUMAN RGS17_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/1zv4_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/1zv4_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zv4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1zv4" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C]]
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[[Category: Large Structures]]
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[[Category: Ball, L]]
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[[Category: Arrowsmith C]]
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[[Category: Bunkoczi, G]]
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[[Category: Ball L]]
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[[Category: Delft, F von]]
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[[Category: Bunkoczi G]]
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[[Category: Doyle, D A]]
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[[Category: Doyle DA]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Elkins, J M]]
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[[Category: Elkins JM]]
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[[Category: Gileadi, O]]
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[[Category: Gileadi O]]
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[[Category: Haroniti, A]]
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[[Category: Haroniti A]]
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[[Category: Jansson, A]]
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[[Category: Jansson A]]
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[[Category: Lee, W H]]
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[[Category: Lee WH]]
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[[Category: Marsden, B]]
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[[Category: Marsden B]]
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[[Category: Niesen, F H]]
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[[Category: Niesen FH]]
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[[Category: Structural genomic]]
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[[Category: Schoch GA]]
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[[Category: Schoch, G A]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M]]
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[[Category: Turnbull AP]]
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[[Category: Turnbull, A P]]
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[[Category: Yang X]]
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[[Category: Yang, X]]
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[[Category: Von Delft F]]
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[[Category: Human rgsz2]]
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[[Category: Mu-opioid receptor interacting protein]]
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[[Category: Regulator of g-protein signaling]]
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[[Category: Regulator of gz-selective protein signaling 2]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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Current revision

Structure of the Regulator of G-Protein Signaling 17 (RGSZ2)

PDB ID 1zv4

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