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4cr0

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==Crystal Structure of H5 (VN1194) Asn186Lys/Gly143Arg Mutant Haemagglutinin==
==Crystal Structure of H5 (VN1194) Asn186Lys/Gly143Arg Mutant Haemagglutinin==
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<StructureSection load='4cr0' size='340' side='right' caption='[[4cr0]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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<StructureSection load='4cr0' size='340' side='right'caption='[[4cr0]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cr0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/vietnam/1194/2004(h5n1)) Influenza a virus (a/vietnam/1194/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CR0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cr0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Vietnam/1194/2004(H5N1)) Influenza A virus (A/Vietnam/1194/2004(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CR0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cqp|4cqp]], [[4cqq|4cqq]], [[4cqr|4cqr]], [[4cqs|4cqs]], [[4cqt|4cqt]], [[4cqu|4cqu]], [[4cqv|4cqv]], [[4cqw|4cqw]], [[4cqx|4cqx]], [[4cqy|4cqy]], [[4cqz|4cqz]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cr0 RCSB], [http://www.ebi.ac.uk/pdbsum/4cr0 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cr0 OCA], [https://pdbe.org/4cr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cr0 RCSB], [https://www.ebi.ac.uk/pdbsum/4cr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cr0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
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[https://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4cr0" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Collins, P J]]
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[[Category: Large Structures]]
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[[Category: Coombs, P J]]
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[[Category: Collins PJ]]
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[[Category: Gamblin, S J]]
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[[Category: Coombs PJ]]
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[[Category: Lin, Y P]]
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[[Category: Gamblin SJ]]
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[[Category: Liu, J]]
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[[Category: Lin YP]]
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[[Category: Martin, S R]]
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[[Category: Liu J]]
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[[Category: McCauley, J W]]
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[[Category: Martin SR]]
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[[Category: Skehel, J J]]
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[[Category: McCauley JW]]
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[[Category: Vachieri, S G]]
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[[Category: Skehel JJ]]
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[[Category: Walker, P A]]
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[[Category: Vachieri SG]]
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[[Category: Xiao, H]]
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[[Category: Walker PA]]
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[[Category: Xiong, X]]
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[[Category: Xiao H]]
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[[Category: 3'sln]]
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[[Category: Xiong X]]
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[[Category: 6'sln]]
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[[Category: Avian flu]]
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[[Category: Glycoprotein]]
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[[Category: Lsta]]
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[[Category: Sialic acid]]
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[[Category: Sialyllactosamine]]
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[[Category: Viral protein]]
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[[Category: Virus receptor]]
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Current revision

Crystal Structure of H5 (VN1194) Asn186Lys/Gly143Arg Mutant Haemagglutinin

PDB ID 4cr0

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