3wbg

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==Structure of the human heart fatty acid-binding protein in complex with 1-anilinonaphtalene-8-sulphonic acid==
==Structure of the human heart fatty acid-binding protein in complex with 1-anilinonaphtalene-8-sulphonic acid==
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<StructureSection load='3wbg' size='340' side='right' caption='[[3wbg]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='3wbg' size='340' side='right'caption='[[3wbg]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wbg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WBG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wbg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WBG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FABP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wbg RCSB], [http://www.ebi.ac.uk/pdbsum/3wbg PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wbg OCA], [https://pdbe.org/3wbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wbg RCSB], [https://www.ebi.ac.uk/pdbsum/3wbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wbg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FABPH_HUMAN FABPH_HUMAN]] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
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[https://www.uniprot.org/uniprot/FABPH_HUMAN FABPH_HUMAN] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Heart-type fatty-acid-binding protein (FABP3), which is a cytosolic protein abundantly found in cardiomyocytes, plays a role in trafficking fatty acids throughout cellular compartments by reversibly binding intracellular fatty acids with relatively high affinity. The fluorescent probe 1-anilinonaphthalene-8-sulfonate (ANS) is extensively utilized for examining the interaction of ligands with fatty-acid-binding proteins. The X-ray structure of FABP3 was determined in the presence of ANS and revealed the detailed ANS-binding mechanism. Furthermore, four water molecules were clearly identified in the binding cavity. Through these water molecules, the bound ANS molecule forms indirect hydrogen-bond interactions with FABP3. The adipocyte-type fatty-acid-binding protein (FABP4) exhibits 67% sequence identity with FABP3 and its crystal structure is almost the same as that of FABP3. However, FABP4 can bind with a higher affinity to ANS than FABP3. To understand the difference in their ligand specificities, a structural comparison was performed between FABP3-ANS and FABP4-ANS complexes. The result revealed that the orientation of ANS binding to FABP3 is completely opposite to that of ANS binding to FABP4, and the substitution of valine in FABP4 to leucine in FABP3 may result in greater steric hindrance between the side-chain of Leu115 and the aniline ring of ANS.
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Structure of the human-heart fatty-acid-binding protein 3 in complex with the fluorescent probe 1-anilinonaphthalene-8-sulphonic acid.,Hirose M, Sugiyama S, Ishida H, Niiyama M, Matsuoka D, Hara T, Mizohata E, Murakami S, Inoue T, Matsuoka S, Murata M J Synchrotron Radiat. 2013 Nov;20(Pt 6):923-8. doi: 10.1107/S0909049513021298., Epub 2013 Oct 1. PMID:24121341<ref>PMID:24121341</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
==See Also==
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*[[Fatty acid-binding protein|Fatty acid-binding protein]]
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*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hara, T]]
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[[Category: Large Structures]]
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[[Category: Hirose, M]]
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[[Category: Hara T]]
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[[Category: Inoue, T]]
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[[Category: Hirose M]]
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[[Category: Ishida, H]]
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[[Category: Inoue T]]
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[[Category: Matsuoka, D]]
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[[Category: Ishida H]]
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[[Category: Matsuoka, S]]
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[[Category: Matsuoka D]]
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[[Category: Mizohata, E]]
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[[Category: Matsuoka S]]
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[[Category: Murakami, S]]
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[[Category: Mizohata E]]
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[[Category: Murata, M]]
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[[Category: Murakami S]]
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[[Category: Niiyama, M]]
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[[Category: Murata M]]
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[[Category: Sato, F]]
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[[Category: Niiyama M]]
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[[Category: Sugiyama, S]]
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[[Category: Sato F]]
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[[Category: Beta barrel]]
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[[Category: Sugiyama S]]
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[[Category: Lipid binding protein]]
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Current revision

Structure of the human heart fatty acid-binding protein in complex with 1-anilinonaphtalene-8-sulphonic acid

PDB ID 3wbg

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