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2e3l

From Proteopedia

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[[Image:2e3l.jpg|left|200px]]
 
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{{Structure
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==Solution Structure of RSGI RUH-068, a GTF2I domain in human cDNA==
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|PDB= 2e3l |SIZE=350|CAPTION= <scene name='initialview01'>2e3l</scene>
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<StructureSection load='2e3l' size='340' side='right'caption='[[2e3l]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2e3l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E3L FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= GTF2IRD2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e3l OCA], [https://pdbe.org/2e3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e3l RCSB], [https://www.ebi.ac.uk/pdbsum/2e3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e3l ProSAT], [https://www.topsan.org/Proteins/RSGI/2e3l TOPSAN]</span></td></tr>
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}}
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</table>
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== Disease ==
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'''Solution Structure of RSGI RUH-068, a GTF2I domain in human cDNA'''
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[https://www.uniprot.org/uniprot/GTD2B_HUMAN GTD2B_HUMAN] GTF2IRD2B is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
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== Function ==
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[https://www.uniprot.org/uniprot/GTD2B_HUMAN GTD2B_HUMAN]
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==About this Structure==
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== Evolutionary Conservation ==
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2E3L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3L OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/2e3l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e3l ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Doi-Katayama, Y.]]
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[[Category: Doi-Katayama Y]]
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[[Category: Hayashi, F.]]
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[[Category: Hayashi F]]
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[[Category: Hirota, H.]]
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[[Category: Hirota H]]
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[[Category: Kurosaki, C.]]
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[[Category: Kurosaki C]]
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[[Category: Nezu, Y.]]
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[[Category: Nezu Y]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Yoshida M]]
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[[Category: Yoshida, M.]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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[[Category: transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:34:52 2008''
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Current revision

Solution Structure of RSGI RUH-068, a GTF2I domain in human cDNA

PDB ID 2e3l

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