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4faj

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==Structure and mode of peptide binding of pheromone receptor PrgZ==
==Structure and mode of peptide binding of pheromone receptor PrgZ==
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<StructureSection load='4faj' size='340' side='right' caption='[[4faj]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4faj' size='340' side='right'caption='[[4faj]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4faj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FAJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FAJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4faj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FAJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">prgZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4faj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4faj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4faj RCSB], [http://www.ebi.ac.uk/pdbsum/4faj PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4faj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4faj OCA], [https://pdbe.org/4faj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4faj RCSB], [https://www.ebi.ac.uk/pdbsum/4faj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4faj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CCF1_ENTFL CCF1_ENTFL]] cCF10 is involved in the conjugative transfer of the hemolysin plasmid pCF10.
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[https://www.uniprot.org/uniprot/Q51643_ENTFL Q51643_ENTFL]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We present the crystal structure of the pheromone receptor protein PrgZ from Enterococcus faecalis in complex with the heptapeptide cCF10 (LVTLVFV), which is used in signaling between conjugative recipient and donor cells. Comparison of PrgZ with homologous oligopeptide-binding proteins (AppA and OppA) explains the high specificity of PrgZ for hydrophobic heptapeptides versus the promiscuity of peptide binding in the homologous proteins.
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Structure and Mode of Peptide Binding of Pheromone Receptor PrgZ.,Berntsson RP, Schuurman-Wolters GK, Dunny G, Slotboom DJ, Poolman B J Biol Chem. 2012 Oct 26;287(44):37165-70. doi: 10.1074/jbc.M112.386334. Epub, 2012 Sep 4. PMID:22948145<ref>PMID:22948145</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
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[[Category: Berntsson, R P-A]]
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[[Category: Large Structures]]
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[[Category: Dunny, K]]
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[[Category: Berntsson RP-A]]
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[[Category: Poolman, B]]
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[[Category: Dunny K]]
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[[Category: Schuurman-Wolters, G K]]
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[[Category: Poolman B]]
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[[Category: Slotboom, D J]]
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[[Category: Schuurman-Wolters GK]]
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[[Category: Extracellular]]
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[[Category: Slotboom DJ]]
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[[Category: Membrane anchored]]
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[[Category: Peptide binding protein]]
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[[Category: Pheromone]]
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[[Category: Substrate binding protein]]
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Current revision

Structure and mode of peptide binding of pheromone receptor PrgZ

PDB ID 4faj

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