3lju

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==Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3==
==Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3==
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<StructureSection load='3lju' size='340' side='right' caption='[[3lju]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3lju' size='340' side='right'caption='[[3lju]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lju]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LJU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LJU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IP9:(2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIOCTANOATE'>IP9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.702&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADAP1, CENTA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IP9:(2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIOCTANOATE'>IP9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lju OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lju RCSB], [http://www.ebi.ac.uk/pdbsum/3lju PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lju OCA], [https://pdbe.org/3lju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lju RCSB], [https://www.ebi.ac.uk/pdbsum/3lju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lju ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ADAP1_HUMAN ADAP1_HUMAN]] GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).<ref>PMID:10448098</ref> <ref>PMID:10333475</ref>
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[https://www.uniprot.org/uniprot/ADAP1_HUMAN ADAP1_HUMAN] GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).<ref>PMID:10448098</ref> <ref>PMID:10333475</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3lju" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M]]
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[[Category: Bountra C]]
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[[Category: MacKenzie, F]]
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[[Category: Edwards AM]]
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[[Category: Park, H]]
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[[Category: MacKenzie F]]
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[[Category: Structural genomic]]
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[[Category: Park H]]
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[[Category: Shen, L]]
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[[Category: Shen L]]
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[[Category: Tempel, W]]
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[[Category: Tempel W]]
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[[Category: Tong, Y]]
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[[Category: Tong Y]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Gap]]
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[[Category: Gtpase activation]]
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[[Category: Hydrolase activator]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Sgc]]
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[[Category: Zinc-finger]]
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Current revision

Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3

PDB ID 3lju

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