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2e5r

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[[Image:2e5r.gif|left|200px]]
 
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{{Structure
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==Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)==
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|PDB= 2e5r |SIZE=350|CAPTION= <scene name='initialview01'>2e5r</scene>
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<StructureSection load='2e5r' size='340' side='right'caption='[[2e5r]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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<table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5R FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= DTNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [https://pdbe.org/2e5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [https://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5r ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>
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</table>
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'''Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)'''
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== Disease ==
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[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[https://omim.org/entry/604169 604169]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref>
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== Function ==
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==Disease==
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[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN] May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
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Known diseases associated with this structure: Left ventricular noncompaction with congenital heart defects OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601239 601239]], Left ventricular noncompaction, familial isolated, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601239 601239]]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2E5R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e5r ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dang, W.]]
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[[Category: Dang W]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y.]]
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[[Category: Muto Y]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M.]]
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[[Category: Terada T]]
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[[Category: Terada, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: ZN]]
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[[Category: dystrobrevin alpha]]
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[[Category: dystrobrevin-alpha]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nmr]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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[[Category: zz domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:35:41 2008''
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Current revision

Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)

PDB ID 2e5r

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