3v3q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:16, 8 November 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with Ethyl 2-[2,3,4 trimethoxy-6(1-octanoyl)phenyl]acetate==
==Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with Ethyl 2-[2,3,4 trimethoxy-6(1-octanoyl)phenyl]acetate==
-
<StructureSection load='3v3q' size='340' side='right' caption='[[3v3q]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
+
<StructureSection load='3v3q' size='340' side='right'caption='[[3v3q]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3v3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V3Q FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3v3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V3Q FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TMY:ETHYL+(2,3,4-TRIMETHOXY-6-OCTANOYLPHENYL)ACETATE'>TMY</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v3e|3v3e]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TMY:ETHYL+(2,3,4-TRIMETHOXY-6-OCTANOYLPHENYL)ACETATE'>TMY</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR4A1, GFRP1, HMR, NAK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3q OCA], [https://pdbe.org/3v3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v3q RCSB], [https://www.ebi.ac.uk/pdbsum/3v3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3q ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v3q RCSB], [http://www.ebi.ac.uk/pdbsum/3v3q PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
+
[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 3v3q" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
Line 23: Line 24:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Chen, Y]]
+
[[Category: Large Structures]]
-
[[Category: Lin, T]]
+
[[Category: Chen Y]]
-
[[Category: Shi, C]]
+
[[Category: Lin T]]
-
[[Category: Wu, Q]]
+
[[Category: Shi C]]
-
[[Category: Yang, K]]
+
[[Category: Wu Q]]
-
[[Category: Zhan, Y]]
+
[[Category: Yang K]]
-
[[Category: Zhang, Q]]
+
[[Category: Zhan Y]]
-
[[Category: Orphan nuclear receptor]]
+
[[Category: Zhang Q]]
-
[[Category: Protein-antagonist complex]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription-antagonist complex]]
+

Current revision

Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with Ethyl 2-[2,3,4 trimethoxy-6(1-octanoyl)phenyl]acetate

PDB ID 3v3q

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3v3q"
Personal tools